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Hypokalemic periodic paralysis as first sign of thyrotoxicosis

Background: periodic paralysis related to hypokalemia is seldom reported in thyrotoxicosis, and it usually occurs in Asian males. Patients and methods: Two Romanian (Caucasian) young patients presented with hypokalemic paralysis. TSH, FT4, TT3 was measured by immunochemiluminescence. Case report 1....

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Autores principales: Trifanescu, RA, Danciulescu Miulescu, R, Carsote, M, Poiana, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624652/
https://www.ncbi.nlm.nih.gov/pubmed/23599824
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author Trifanescu, RA
Danciulescu Miulescu, R
Carsote, M
Poiana, C
author_facet Trifanescu, RA
Danciulescu Miulescu, R
Carsote, M
Poiana, C
author_sort Trifanescu, RA
collection PubMed
description Background: periodic paralysis related to hypokalemia is seldom reported in thyrotoxicosis, and it usually occurs in Asian males. Patients and methods: Two Romanian (Caucasian) young patients presented with hypokalemic paralysis. TSH, FT4, TT3 was measured by immunochemiluminescence. Case report 1. Patient O.R, aged 19, presented marked asthenia and lower limbs paralysis, following high carbohydrate meal. He declared 10 kg weight loss on hypocaloric diet and mild sweating. Biochemical data revealed moderate hypokalemia (K+=2.6 mmol/L) and thyrotoxicosis (TSH<0.03 mIU/L, FT4=30 pmol/L, TT3=315 ng/dL). Case report 2. Patient T.A., aged 18, presented 2 episodes of weakness and flaccid paralysis, with hypokalemia, precipitated by effort, without any sign of thyrotoxicosis. Biochemical data revealed severe hypokalemia (K+=1.8 mmol/L) and thyrotoxicosis (TSH<0.03 mIU/L, FT4=24 pmol/L, TT3=190 ng/dL). Treatment with intravenous potassium, thereafter methimazole and propranolol were administered in both cases, with the maintenance of normal kalemia and thyrotoxicosis’ control. Conclusion: these 2 cases of hypokalemic periodic paralysis occurring in young Caucasian teenagers with mild thyrotoxicosis underlined the importance of thyroid screening in patients with symptomatic hypokalemia, even in the absence of symptoms and signs of thyrotoxicosis. Abbreviations: THPP=Thyrotoxic periodic paralysis, BMI=body mass index, TRAb=TSH receptor antibody, ECG=electrocardiogram.
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spelling pubmed-36246522013-05-15 Hypokalemic periodic paralysis as first sign of thyrotoxicosis Trifanescu, RA Danciulescu Miulescu, R Carsote, M Poiana, C J Med Life Case Presentation Background: periodic paralysis related to hypokalemia is seldom reported in thyrotoxicosis, and it usually occurs in Asian males. Patients and methods: Two Romanian (Caucasian) young patients presented with hypokalemic paralysis. TSH, FT4, TT3 was measured by immunochemiluminescence. Case report 1. Patient O.R, aged 19, presented marked asthenia and lower limbs paralysis, following high carbohydrate meal. He declared 10 kg weight loss on hypocaloric diet and mild sweating. Biochemical data revealed moderate hypokalemia (K+=2.6 mmol/L) and thyrotoxicosis (TSH<0.03 mIU/L, FT4=30 pmol/L, TT3=315 ng/dL). Case report 2. Patient T.A., aged 18, presented 2 episodes of weakness and flaccid paralysis, with hypokalemia, precipitated by effort, without any sign of thyrotoxicosis. Biochemical data revealed severe hypokalemia (K+=1.8 mmol/L) and thyrotoxicosis (TSH<0.03 mIU/L, FT4=24 pmol/L, TT3=190 ng/dL). Treatment with intravenous potassium, thereafter methimazole and propranolol were administered in both cases, with the maintenance of normal kalemia and thyrotoxicosis’ control. Conclusion: these 2 cases of hypokalemic periodic paralysis occurring in young Caucasian teenagers with mild thyrotoxicosis underlined the importance of thyroid screening in patients with symptomatic hypokalemia, even in the absence of symptoms and signs of thyrotoxicosis. Abbreviations: THPP=Thyrotoxic periodic paralysis, BMI=body mass index, TRAb=TSH receptor antibody, ECG=electrocardiogram. Carol Davila University Press 2013-03-15 2013-03-25 /pmc/articles/PMC3624652/ /pubmed/23599824 Text en ©Carol Davila University Press http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Presentation
Trifanescu, RA
Danciulescu Miulescu, R
Carsote, M
Poiana, C
Hypokalemic periodic paralysis as first sign of thyrotoxicosis
title Hypokalemic periodic paralysis as first sign of thyrotoxicosis
title_full Hypokalemic periodic paralysis as first sign of thyrotoxicosis
title_fullStr Hypokalemic periodic paralysis as first sign of thyrotoxicosis
title_full_unstemmed Hypokalemic periodic paralysis as first sign of thyrotoxicosis
title_short Hypokalemic periodic paralysis as first sign of thyrotoxicosis
title_sort hypokalemic periodic paralysis as first sign of thyrotoxicosis
topic Case Presentation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624652/
https://www.ncbi.nlm.nih.gov/pubmed/23599824
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