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Atypical femoral fractures related to bisphosphonate therapy

Bisphosphonates (BP) are a commonly prescribed class of drugs for the prevention of osteoporosis-related fractures. Paradoxically, however, they have recently been linked to atypical fractures in the shaft of the femur. Since many physicians including radiologists, are not aware of this entity, the...

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Detalles Bibliográficos
Autores principales: Jain, Tarun Pankaj, Thorn, Murray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624739/
https://www.ncbi.nlm.nih.gov/pubmed/23599564
http://dx.doi.org/10.4103/0971-3026.107178
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author Jain, Tarun Pankaj
Thorn, Murray
author_facet Jain, Tarun Pankaj
Thorn, Murray
author_sort Jain, Tarun Pankaj
collection PubMed
description Bisphosphonates (BP) are a commonly prescribed class of drugs for the prevention of osteoporosis-related fractures. Paradoxically, however, they have recently been linked to atypical fractures in the shaft of the femur. Since many physicians including radiologists, are not aware of this entity, the incidence is likely underreported. These fractures usually occur in the sub-trochanteric region of the femur in the setting of low-energy trauma. It starts as a fracture line involving the lateral cortex and then progresses medially to give rise to a complete fracture. The fracture line is usually transverse, and there is a medial spike associated with a complete fracture. These fractures can be bilateral. Awareness of these atypical fractures and their radiological appearance should enable their early and accurate detection and thus lead to specific treatment.
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spelling pubmed-36247392013-04-18 Atypical femoral fractures related to bisphosphonate therapy Jain, Tarun Pankaj Thorn, Murray Indian J Radiol Imaging Musculoskeletal Imaging Bisphosphonates (BP) are a commonly prescribed class of drugs for the prevention of osteoporosis-related fractures. Paradoxically, however, they have recently been linked to atypical fractures in the shaft of the femur. Since many physicians including radiologists, are not aware of this entity, the incidence is likely underreported. These fractures usually occur in the sub-trochanteric region of the femur in the setting of low-energy trauma. It starts as a fracture line involving the lateral cortex and then progresses medially to give rise to a complete fracture. The fracture line is usually transverse, and there is a medial spike associated with a complete fracture. These fractures can be bilateral. Awareness of these atypical fractures and their radiological appearance should enable their early and accurate detection and thus lead to specific treatment. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3624739/ /pubmed/23599564 http://dx.doi.org/10.4103/0971-3026.107178 Text en Copyright: © Indian Journal of Radiology and Imaging http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Musculoskeletal Imaging
Jain, Tarun Pankaj
Thorn, Murray
Atypical femoral fractures related to bisphosphonate therapy
title Atypical femoral fractures related to bisphosphonate therapy
title_full Atypical femoral fractures related to bisphosphonate therapy
title_fullStr Atypical femoral fractures related to bisphosphonate therapy
title_full_unstemmed Atypical femoral fractures related to bisphosphonate therapy
title_short Atypical femoral fractures related to bisphosphonate therapy
title_sort atypical femoral fractures related to bisphosphonate therapy
topic Musculoskeletal Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624739/
https://www.ncbi.nlm.nih.gov/pubmed/23599564
http://dx.doi.org/10.4103/0971-3026.107178
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