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Atypical femoral fractures related to bisphosphonate therapy
Bisphosphonates (BP) are a commonly prescribed class of drugs for the prevention of osteoporosis-related fractures. Paradoxically, however, they have recently been linked to atypical fractures in the shaft of the femur. Since many physicians including radiologists, are not aware of this entity, the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624739/ https://www.ncbi.nlm.nih.gov/pubmed/23599564 http://dx.doi.org/10.4103/0971-3026.107178 |
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author | Jain, Tarun Pankaj Thorn, Murray |
author_facet | Jain, Tarun Pankaj Thorn, Murray |
author_sort | Jain, Tarun Pankaj |
collection | PubMed |
description | Bisphosphonates (BP) are a commonly prescribed class of drugs for the prevention of osteoporosis-related fractures. Paradoxically, however, they have recently been linked to atypical fractures in the shaft of the femur. Since many physicians including radiologists, are not aware of this entity, the incidence is likely underreported. These fractures usually occur in the sub-trochanteric region of the femur in the setting of low-energy trauma. It starts as a fracture line involving the lateral cortex and then progresses medially to give rise to a complete fracture. The fracture line is usually transverse, and there is a medial spike associated with a complete fracture. These fractures can be bilateral. Awareness of these atypical fractures and their radiological appearance should enable their early and accurate detection and thus lead to specific treatment. |
format | Online Article Text |
id | pubmed-3624739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-36247392013-04-18 Atypical femoral fractures related to bisphosphonate therapy Jain, Tarun Pankaj Thorn, Murray Indian J Radiol Imaging Musculoskeletal Imaging Bisphosphonates (BP) are a commonly prescribed class of drugs for the prevention of osteoporosis-related fractures. Paradoxically, however, they have recently been linked to atypical fractures in the shaft of the femur. Since many physicians including radiologists, are not aware of this entity, the incidence is likely underreported. These fractures usually occur in the sub-trochanteric region of the femur in the setting of low-energy trauma. It starts as a fracture line involving the lateral cortex and then progresses medially to give rise to a complete fracture. The fracture line is usually transverse, and there is a medial spike associated with a complete fracture. These fractures can be bilateral. Awareness of these atypical fractures and their radiological appearance should enable their early and accurate detection and thus lead to specific treatment. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3624739/ /pubmed/23599564 http://dx.doi.org/10.4103/0971-3026.107178 Text en Copyright: © Indian Journal of Radiology and Imaging http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Musculoskeletal Imaging Jain, Tarun Pankaj Thorn, Murray Atypical femoral fractures related to bisphosphonate therapy |
title | Atypical femoral fractures related to bisphosphonate therapy |
title_full | Atypical femoral fractures related to bisphosphonate therapy |
title_fullStr | Atypical femoral fractures related to bisphosphonate therapy |
title_full_unstemmed | Atypical femoral fractures related to bisphosphonate therapy |
title_short | Atypical femoral fractures related to bisphosphonate therapy |
title_sort | atypical femoral fractures related to bisphosphonate therapy |
topic | Musculoskeletal Imaging |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624739/ https://www.ncbi.nlm.nih.gov/pubmed/23599564 http://dx.doi.org/10.4103/0971-3026.107178 |
work_keys_str_mv | AT jaintarunpankaj atypicalfemoralfracturesrelatedtobisphosphonatetherapy AT thornmurray atypicalfemoralfracturesrelatedtobisphosphonatetherapy |