Mitotic Spindle Defects and Chromosome Mis-Segregation Induced by LDL/Cholesterol—Implications for Niemann-Pick C1, Alzheimer’s Disease, and Atherosclerosis

Elevated low-density lipoprotein (LDL)-cholesterol is a risk factor for both Alzheimer’s disease (AD) and Atherosclerosis (CVD), suggesting a common lipid-sensitive step in their pathogenesis. Previous results show that AD and CVD also share a cell cycle defect: chromosome instability and up to 30%...

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Detalles Bibliográficos
Autores principales: Granic, Antoneta, Potter, Huntington
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625184/
https://www.ncbi.nlm.nih.gov/pubmed/23593294
http://dx.doi.org/10.1371/journal.pone.0060718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625184/
https://www.ncbi.nlm.nih.gov/pubmed/23593294
http://dx.doi.org/10.1371/journal.pone.0060718

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