DNA Variation in the SNAP25 Gene Confers Risk to ADHD and Is Associated with Reduced Expression in Prefrontal Cortex

BACKGROUND: The Coloboma mouse carries a ∼2 cM deletion encompassing the SNAP25 gene and has a hyperactive phenotype similar to that of ADHD. Such mice are 3 fold more active compared to their control littermates. Genetic association studies support a role for allelic variants of the human SNAP25 ge...

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Detalles Bibliográficos
Autores principales: Hawi, Ziarih, Matthews, Natasha, Wagner, Joseph, Wallace, Robyn H., Butler, Tim J., Vance, Alasdair, Kent, Lindsey, Gill, Michael, Bellgrove, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625226/
https://www.ncbi.nlm.nih.gov/pubmed/23593184
http://dx.doi.org/10.1371/journal.pone.0060274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625226/
https://www.ncbi.nlm.nih.gov/pubmed/23593184
http://dx.doi.org/10.1371/journal.pone.0060274

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