Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans

Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. Here, by integrating transcriptional analysis and functional genomics, we identified Candida-specific host defense mechanisms in humans. Candi...

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Detalles Bibliográficos
Autores principales: Smeekens, Sanne P., Ng, Aylwin, Kumar, Vinod, Johnson, Melissa D., Plantinga, Theo S., van Diemen, Cleo, Arts, Peer, Verwiel, Eugéne T.P., Gresnigt, Mark S., Fransen, Karin, van Sommeren, Suzanne, Oosting, Marije, Cheng, Shih-Chin, Joosten, Leo A.B., Hoischen, Alexander, Kullberg, Bart-Jan, Scott, William K., Perfect, John R., van der Meer, Jos W.M., Wijmenga, Cisca, Netea, Mihai G., Xavier, Ramnik J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625375/
https://www.ncbi.nlm.nih.gov/pubmed/23299892
http://dx.doi.org/10.1038/ncomms2343

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