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Recurrence risk in small, node-negative, early breast cancer: a multicenter retrospective analysis

PURPOSE: Recurrences and deaths are known to occur, even if less frequently, in small, node-negative breast cancer patients, and decision on adjuvant treatments remains controversial. In the present analysis, we evaluate recurrence risk in patients with pT1 a, b, c, node-negative, breast cancer, acc...

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Autores principales: Gamucci, T., Vaccaro, A., Ciancola, F., Pizzuti, L., Sperduti, I., Moscetti, L., Longo, F., Fabbri, M. A., Giampaolo, M. A., Mentuccia, L., Di Lauro, L., Vici, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625404/
https://www.ncbi.nlm.nih.gov/pubmed/23411686
http://dx.doi.org/10.1007/s00432-013-1388-2
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author Gamucci, T.
Vaccaro, A.
Ciancola, F.
Pizzuti, L.
Sperduti, I.
Moscetti, L.
Longo, F.
Fabbri, M. A.
Giampaolo, M. A.
Mentuccia, L.
Di Lauro, L.
Vici, P.
author_facet Gamucci, T.
Vaccaro, A.
Ciancola, F.
Pizzuti, L.
Sperduti, I.
Moscetti, L.
Longo, F.
Fabbri, M. A.
Giampaolo, M. A.
Mentuccia, L.
Di Lauro, L.
Vici, P.
author_sort Gamucci, T.
collection PubMed
description PURPOSE: Recurrences and deaths are known to occur, even if less frequently, in small, node-negative breast cancer patients, and decision on adjuvant treatments remains controversial. In the present analysis, we evaluate recurrence risk in patients with pT1 a, b, c, node-negative, breast cancer, accordingly with some prognostic biological factors. METHODS: We retrospectively evaluated 900 node-negative patients (pT1a, b, c) surgery treated between 2000 and 2009 in four Italian oncologic centers. We defined 3 different cohorts: ER positive (ER+); Her-2 positive (Her-2+); and triple negative (TN). RESULTS: pT1a was seen in 7.6% of patients, 37.7 % pT1b, 54.8 % pT1c. Concerning the 3 different cohorts, 58.2 % were ER+; 10.8 % were Her-2+; 8.2 % were TN. Overall, chemotherapy was given to 3.0 %, 27.2 %, 69.8 % of pT1a, b, c, respectively, and to 22.7 %, 58.8 %, 68.9 % of ER+, Her-2+, TN subgroups. At a median follow-up of 67 months, 5-year DFS was 96.3 %, 89.2 %, 89.4 % in pT1a, b, c, respectively (100 %, 93.6 %, 89.8 % in ER+; 100 %, 78.7 %, 85.0 % in Her-2+; 100 %, 76.8 %, 85.2 % in TN) (p = ns). At multivariate analysis, histologic grade and Ki-67 resulted independent prognostic factors. Overall, 5-year OS was 98 %, without differences among pT1a, b, c, or among the 3 cohorts. CONCLUSIONS: Overall, 5-year DFS was very favorable in this series of small, node-negative breast cancers, but Her-2+ and TN cohorts have a higher recurrence rate than ER+ cohort (p < 0.0001); pT1c, but also pT1b, in Her-2+ and TN subgroups, have a worse outcome, and effective chemotherapy treatment should be considered in these unfavorable subgroups.
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spelling pubmed-36254042013-04-15 Recurrence risk in small, node-negative, early breast cancer: a multicenter retrospective analysis Gamucci, T. Vaccaro, A. Ciancola, F. Pizzuti, L. Sperduti, I. Moscetti, L. Longo, F. Fabbri, M. A. Giampaolo, M. A. Mentuccia, L. Di Lauro, L. Vici, P. J Cancer Res Clin Oncol Original Paper PURPOSE: Recurrences and deaths are known to occur, even if less frequently, in small, node-negative breast cancer patients, and decision on adjuvant treatments remains controversial. In the present analysis, we evaluate recurrence risk in patients with pT1 a, b, c, node-negative, breast cancer, accordingly with some prognostic biological factors. METHODS: We retrospectively evaluated 900 node-negative patients (pT1a, b, c) surgery treated between 2000 and 2009 in four Italian oncologic centers. We defined 3 different cohorts: ER positive (ER+); Her-2 positive (Her-2+); and triple negative (TN). RESULTS: pT1a was seen in 7.6% of patients, 37.7 % pT1b, 54.8 % pT1c. Concerning the 3 different cohorts, 58.2 % were ER+; 10.8 % were Her-2+; 8.2 % were TN. Overall, chemotherapy was given to 3.0 %, 27.2 %, 69.8 % of pT1a, b, c, respectively, and to 22.7 %, 58.8 %, 68.9 % of ER+, Her-2+, TN subgroups. At a median follow-up of 67 months, 5-year DFS was 96.3 %, 89.2 %, 89.4 % in pT1a, b, c, respectively (100 %, 93.6 %, 89.8 % in ER+; 100 %, 78.7 %, 85.0 % in Her-2+; 100 %, 76.8 %, 85.2 % in TN) (p = ns). At multivariate analysis, histologic grade and Ki-67 resulted independent prognostic factors. Overall, 5-year OS was 98 %, without differences among pT1a, b, c, or among the 3 cohorts. CONCLUSIONS: Overall, 5-year DFS was very favorable in this series of small, node-negative breast cancers, but Her-2+ and TN cohorts have a higher recurrence rate than ER+ cohort (p < 0.0001); pT1c, but also pT1b, in Her-2+ and TN subgroups, have a worse outcome, and effective chemotherapy treatment should be considered in these unfavorable subgroups. Springer-Verlag 2013-02-15 2013 /pmc/articles/PMC3625404/ /pubmed/23411686 http://dx.doi.org/10.1007/s00432-013-1388-2 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Paper
Gamucci, T.
Vaccaro, A.
Ciancola, F.
Pizzuti, L.
Sperduti, I.
Moscetti, L.
Longo, F.
Fabbri, M. A.
Giampaolo, M. A.
Mentuccia, L.
Di Lauro, L.
Vici, P.
Recurrence risk in small, node-negative, early breast cancer: a multicenter retrospective analysis
title Recurrence risk in small, node-negative, early breast cancer: a multicenter retrospective analysis
title_full Recurrence risk in small, node-negative, early breast cancer: a multicenter retrospective analysis
title_fullStr Recurrence risk in small, node-negative, early breast cancer: a multicenter retrospective analysis
title_full_unstemmed Recurrence risk in small, node-negative, early breast cancer: a multicenter retrospective analysis
title_short Recurrence risk in small, node-negative, early breast cancer: a multicenter retrospective analysis
title_sort recurrence risk in small, node-negative, early breast cancer: a multicenter retrospective analysis
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625404/
https://www.ncbi.nlm.nih.gov/pubmed/23411686
http://dx.doi.org/10.1007/s00432-013-1388-2
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