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Inflammasome in Intestinal Inflammation and Cancer
The activation of specific cytosolic pathogen recognition receptors, the nucleotide-binding-oligomerization-domain- (NOD-) like receptors (NLRs), leads to the assembly of the inflammasome, a multimeric complex platform that activates caspase-1. The caspase-1 pathway leads to the upregulation of impo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625567/ https://www.ncbi.nlm.nih.gov/pubmed/23606794 http://dx.doi.org/10.1155/2013/654963 |
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author | Nunes, Tiago de Souza, Heitor S. |
author_facet | Nunes, Tiago de Souza, Heitor S. |
author_sort | Nunes, Tiago |
collection | PubMed |
description | The activation of specific cytosolic pathogen recognition receptors, the nucleotide-binding-oligomerization-domain- (NOD-) like receptors (NLRs), leads to the assembly of the inflammasome, a multimeric complex platform that activates caspase-1. The caspase-1 pathway leads to the upregulation of important cytokines from the interleukin (IL)-1 family, IL-1β, and IL-18, with subsequent activation of the innate immune response. In this review, we discuss the molecular structure, the mechanisms behind the inflammasome activation, and its possible role in the pathogenesis of inflammatory bowel diseases and intestinal cancer. Here, we show that the available data points towards the importance of the inflammasome in the innate intestinal immune response, being the complex involved in the maintenance of intestinal homeostasis, correct intestinal barrier function and efficient elimination of invading pathogens. |
format | Online Article Text |
id | pubmed-3625567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36255672013-04-19 Inflammasome in Intestinal Inflammation and Cancer Nunes, Tiago de Souza, Heitor S. Mediators Inflamm Review Article The activation of specific cytosolic pathogen recognition receptors, the nucleotide-binding-oligomerization-domain- (NOD-) like receptors (NLRs), leads to the assembly of the inflammasome, a multimeric complex platform that activates caspase-1. The caspase-1 pathway leads to the upregulation of important cytokines from the interleukin (IL)-1 family, IL-1β, and IL-18, with subsequent activation of the innate immune response. In this review, we discuss the molecular structure, the mechanisms behind the inflammasome activation, and its possible role in the pathogenesis of inflammatory bowel diseases and intestinal cancer. Here, we show that the available data points towards the importance of the inflammasome in the innate intestinal immune response, being the complex involved in the maintenance of intestinal homeostasis, correct intestinal barrier function and efficient elimination of invading pathogens. Hindawi Publishing Corporation 2013 2013-03-28 /pmc/articles/PMC3625567/ /pubmed/23606794 http://dx.doi.org/10.1155/2013/654963 Text en Copyright © 2013 T. Nunes and H. S. de Souza. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Nunes, Tiago de Souza, Heitor S. Inflammasome in Intestinal Inflammation and Cancer |
title | Inflammasome in Intestinal Inflammation and Cancer |
title_full | Inflammasome in Intestinal Inflammation and Cancer |
title_fullStr | Inflammasome in Intestinal Inflammation and Cancer |
title_full_unstemmed | Inflammasome in Intestinal Inflammation and Cancer |
title_short | Inflammasome in Intestinal Inflammation and Cancer |
title_sort | inflammasome in intestinal inflammation and cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625567/ https://www.ncbi.nlm.nih.gov/pubmed/23606794 http://dx.doi.org/10.1155/2013/654963 |
work_keys_str_mv | AT nunestiago inflammasomeinintestinalinflammationandcancer AT desouzaheitors inflammasomeinintestinalinflammationandcancer |