Cargando…

Inflammasome in Intestinal Inflammation and Cancer

The activation of specific cytosolic pathogen recognition receptors, the nucleotide-binding-oligomerization-domain- (NOD-) like receptors (NLRs), leads to the assembly of the inflammasome, a multimeric complex platform that activates caspase-1. The caspase-1 pathway leads to the upregulation of impo...

Descripción completa

Detalles Bibliográficos
Autores principales: Nunes, Tiago, de Souza, Heitor S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625567/
https://www.ncbi.nlm.nih.gov/pubmed/23606794
http://dx.doi.org/10.1155/2013/654963
_version_ 1782266104618418176
author Nunes, Tiago
de Souza, Heitor S.
author_facet Nunes, Tiago
de Souza, Heitor S.
author_sort Nunes, Tiago
collection PubMed
description The activation of specific cytosolic pathogen recognition receptors, the nucleotide-binding-oligomerization-domain- (NOD-) like receptors (NLRs), leads to the assembly of the inflammasome, a multimeric complex platform that activates caspase-1. The caspase-1 pathway leads to the upregulation of important cytokines from the interleukin (IL)-1 family, IL-1β, and IL-18, with subsequent activation of the innate immune response. In this review, we discuss the molecular structure, the mechanisms behind the inflammasome activation, and its possible role in the pathogenesis of inflammatory bowel diseases and intestinal cancer. Here, we show that the available data points towards the importance of the inflammasome in the innate intestinal immune response, being the complex involved in the maintenance of intestinal homeostasis, correct intestinal barrier function and efficient elimination of invading pathogens.
format Online
Article
Text
id pubmed-3625567
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-36255672013-04-19 Inflammasome in Intestinal Inflammation and Cancer Nunes, Tiago de Souza, Heitor S. Mediators Inflamm Review Article The activation of specific cytosolic pathogen recognition receptors, the nucleotide-binding-oligomerization-domain- (NOD-) like receptors (NLRs), leads to the assembly of the inflammasome, a multimeric complex platform that activates caspase-1. The caspase-1 pathway leads to the upregulation of important cytokines from the interleukin (IL)-1 family, IL-1β, and IL-18, with subsequent activation of the innate immune response. In this review, we discuss the molecular structure, the mechanisms behind the inflammasome activation, and its possible role in the pathogenesis of inflammatory bowel diseases and intestinal cancer. Here, we show that the available data points towards the importance of the inflammasome in the innate intestinal immune response, being the complex involved in the maintenance of intestinal homeostasis, correct intestinal barrier function and efficient elimination of invading pathogens. Hindawi Publishing Corporation 2013 2013-03-28 /pmc/articles/PMC3625567/ /pubmed/23606794 http://dx.doi.org/10.1155/2013/654963 Text en Copyright © 2013 T. Nunes and H. S. de Souza. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Nunes, Tiago
de Souza, Heitor S.
Inflammasome in Intestinal Inflammation and Cancer
title Inflammasome in Intestinal Inflammation and Cancer
title_full Inflammasome in Intestinal Inflammation and Cancer
title_fullStr Inflammasome in Intestinal Inflammation and Cancer
title_full_unstemmed Inflammasome in Intestinal Inflammation and Cancer
title_short Inflammasome in Intestinal Inflammation and Cancer
title_sort inflammasome in intestinal inflammation and cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625567/
https://www.ncbi.nlm.nih.gov/pubmed/23606794
http://dx.doi.org/10.1155/2013/654963
work_keys_str_mv AT nunestiago inflammasomeinintestinalinflammationandcancer
AT desouzaheitors inflammasomeinintestinalinflammationandcancer