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Duration of Intrapartum Antibiotics for Group B Streptococcus on the Diagnosis of Clinical Neonatal Sepsis

Background. Infants born to mothers who are colonized with group B streptococcus (GBS) but received <4 hours of intrapartum antibiotic prophylaxis (IAP) are at-risk for presenting later with sepsis. We assessed if <4 hours of maternal IAP for GBS are associated with an increased incidence of c...

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Autores principales: Turrentine, Mark A., Greisinger, Anthony J., Brown, Kimberly S., Wehmanen, Oscar A., Mouzoon, Melanie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625608/
https://www.ncbi.nlm.nih.gov/pubmed/23606801
http://dx.doi.org/10.1155/2013/525878
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author Turrentine, Mark A.
Greisinger, Anthony J.
Brown, Kimberly S.
Wehmanen, Oscar A.
Mouzoon, Melanie E.
author_facet Turrentine, Mark A.
Greisinger, Anthony J.
Brown, Kimberly S.
Wehmanen, Oscar A.
Mouzoon, Melanie E.
author_sort Turrentine, Mark A.
collection PubMed
description Background. Infants born to mothers who are colonized with group B streptococcus (GBS) but received <4 hours of intrapartum antibiotic prophylaxis (IAP) are at-risk for presenting later with sepsis. We assessed if <4 hours of maternal IAP for GBS are associated with an increased incidence of clinical neonatal sepsis. Materials and Methods. A retrospective cohort study of women-infant dyads undergoing IAP for GBS at ≥37-week gestation who presented in labor from January 1, 2003 through December 31, 2007 was performed. Infants diagnosed with clinical sepsis by the duration of maternal IAP received (< or ≥4-hours duration) were determined. Results. More infants whose mothers received <4 hours of IAP were diagnosed with clinical sepsis, 13 of 1,149 (1.1%) versus 15 of 3,633 (0.4%), P = .03. Multivariate logistic regression analysis showed that treatment with ≥4 hours of IAP reduced the risk of infants being diagnosed with clinical sepsis by 65%, adjusted relative risk 0.35, CI 0.16–0.79, and P = .01. Conclusion. The rate of neonatal clinical sepsis is increased in newborns of GBS colonized mothers who receive <4 hours compared to ≥4 hours of IAP.
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spelling pubmed-36256082013-04-19 Duration of Intrapartum Antibiotics for Group B Streptococcus on the Diagnosis of Clinical Neonatal Sepsis Turrentine, Mark A. Greisinger, Anthony J. Brown, Kimberly S. Wehmanen, Oscar A. Mouzoon, Melanie E. Infect Dis Obstet Gynecol Clinical Study Background. Infants born to mothers who are colonized with group B streptococcus (GBS) but received <4 hours of intrapartum antibiotic prophylaxis (IAP) are at-risk for presenting later with sepsis. We assessed if <4 hours of maternal IAP for GBS are associated with an increased incidence of clinical neonatal sepsis. Materials and Methods. A retrospective cohort study of women-infant dyads undergoing IAP for GBS at ≥37-week gestation who presented in labor from January 1, 2003 through December 31, 2007 was performed. Infants diagnosed with clinical sepsis by the duration of maternal IAP received (< or ≥4-hours duration) were determined. Results. More infants whose mothers received <4 hours of IAP were diagnosed with clinical sepsis, 13 of 1,149 (1.1%) versus 15 of 3,633 (0.4%), P = .03. Multivariate logistic regression analysis showed that treatment with ≥4 hours of IAP reduced the risk of infants being diagnosed with clinical sepsis by 65%, adjusted relative risk 0.35, CI 0.16–0.79, and P = .01. Conclusion. The rate of neonatal clinical sepsis is increased in newborns of GBS colonized mothers who receive <4 hours compared to ≥4 hours of IAP. Hindawi Publishing Corporation 2013 2013-03-28 /pmc/articles/PMC3625608/ /pubmed/23606801 http://dx.doi.org/10.1155/2013/525878 Text en Copyright © 2013 Mark A. Turrentine et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Turrentine, Mark A.
Greisinger, Anthony J.
Brown, Kimberly S.
Wehmanen, Oscar A.
Mouzoon, Melanie E.
Duration of Intrapartum Antibiotics for Group B Streptococcus on the Diagnosis of Clinical Neonatal Sepsis
title Duration of Intrapartum Antibiotics for Group B Streptococcus on the Diagnosis of Clinical Neonatal Sepsis
title_full Duration of Intrapartum Antibiotics for Group B Streptococcus on the Diagnosis of Clinical Neonatal Sepsis
title_fullStr Duration of Intrapartum Antibiotics for Group B Streptococcus on the Diagnosis of Clinical Neonatal Sepsis
title_full_unstemmed Duration of Intrapartum Antibiotics for Group B Streptococcus on the Diagnosis of Clinical Neonatal Sepsis
title_short Duration of Intrapartum Antibiotics for Group B Streptococcus on the Diagnosis of Clinical Neonatal Sepsis
title_sort duration of intrapartum antibiotics for group b streptococcus on the diagnosis of clinical neonatal sepsis
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625608/
https://www.ncbi.nlm.nih.gov/pubmed/23606801
http://dx.doi.org/10.1155/2013/525878
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