MEK1 Is Required for PTEN Membrane Recruitment, AKT Regulation, and the Maintenance of Peripheral Tolerance

The Raf/MEK/ERK and PI3K/Akt pathways are prominent effectors of oncogenic Ras. These pathways negatively regulate each other, but the mechanism involved is incompletely understood. We now identify MEK1 as an essential regulator of lipid/protein phosphatase PTEN, through which it controls phosphatid...

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Detalles Bibliográficos
Autores principales: Zmajkovicova, Katarina, Jesenberger, Veronika, Catalanotti, Federica, Baumgartner, Christian, Reyes, Gloria, Baccarini, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625979/
https://www.ncbi.nlm.nih.gov/pubmed/23453810
http://dx.doi.org/10.1016/j.molcel.2013.01.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625979/
https://www.ncbi.nlm.nih.gov/pubmed/23453810
http://dx.doi.org/10.1016/j.molcel.2013.01.037

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