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Focus On: The Use of Animal Models for the Study of Fetal Alcohol Spectrum Disorders
Considerable efforts to educate women not to abuse alcohol during pregnancy have failed to reduce the incidence of fetal alcohol syndrome. Therefore, other approaches to limit the effects of prenatal alcohol exposure are under consideration, including the development of prevention programs and inter...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute on Alcohol Abuse and Alcoholism
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625987/ https://www.ncbi.nlm.nih.gov/pubmed/23580046 |
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author | Wilson, Shannon E. Cudd, Timothy A. |
author_facet | Wilson, Shannon E. Cudd, Timothy A. |
author_sort | Wilson, Shannon E. |
collection | PubMed |
description | Considerable efforts to educate women not to abuse alcohol during pregnancy have failed to reduce the incidence of fetal alcohol syndrome. Therefore, other approaches to limit the effects of prenatal alcohol exposure are under consideration, including the development of prevention programs and interventions. For these strategies to be as successful as possible, it also is important to improve methods for identifying affected children. The use of animal models in prenatal alcohol exposure research is critical because of the practical and ethical limitations of using human subjects for such studies. This article reviews the use of animal models in three areas of research: addressing basic questions about alcohol exposure during development; improving the identification of affected individuals; and developing approaches to reduce the impact of prenatal alcohol exposure. The various animal-model systems that have been used to study fetal alcohol spectrum disorders, each with their own specific strengths, have provided new findings that have been successfully extrapolated to human subjects, resulting in advancement of the research field and our understanding of fetal alcohol spectrum disorders. |
format | Online Article Text |
id | pubmed-3625987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | National Institute on Alcohol Abuse and Alcoholism |
record_format | MEDLINE/PubMed |
spelling | pubmed-36259872013-04-15 Focus On: The Use of Animal Models for the Study of Fetal Alcohol Spectrum Disorders Wilson, Shannon E. Cudd, Timothy A. Alcohol Res Health Update on Animal Models Considerable efforts to educate women not to abuse alcohol during pregnancy have failed to reduce the incidence of fetal alcohol syndrome. Therefore, other approaches to limit the effects of prenatal alcohol exposure are under consideration, including the development of prevention programs and interventions. For these strategies to be as successful as possible, it also is important to improve methods for identifying affected children. The use of animal models in prenatal alcohol exposure research is critical because of the practical and ethical limitations of using human subjects for such studies. This article reviews the use of animal models in three areas of research: addressing basic questions about alcohol exposure during development; improving the identification of affected individuals; and developing approaches to reduce the impact of prenatal alcohol exposure. The various animal-model systems that have been used to study fetal alcohol spectrum disorders, each with their own specific strengths, have provided new findings that have been successfully extrapolated to human subjects, resulting in advancement of the research field and our understanding of fetal alcohol spectrum disorders. National Institute on Alcohol Abuse and Alcoholism 2011 /pmc/articles/PMC3625987/ /pubmed/23580046 Text en http://creativecommons.org/publicdomain/mark/1.0/ Unless otherwise noted in the text, all material appearing in this journal is in the public domain and may be reproduced without permission. Citation of the source is appreciated. |
spellingShingle | Update on Animal Models Wilson, Shannon E. Cudd, Timothy A. Focus On: The Use of Animal Models for the Study of Fetal Alcohol Spectrum Disorders |
title | Focus On: The Use of Animal Models for the Study of Fetal Alcohol Spectrum Disorders |
title_full | Focus On: The Use of Animal Models for the Study of Fetal Alcohol Spectrum Disorders |
title_fullStr | Focus On: The Use of Animal Models for the Study of Fetal Alcohol Spectrum Disorders |
title_full_unstemmed | Focus On: The Use of Animal Models for the Study of Fetal Alcohol Spectrum Disorders |
title_short | Focus On: The Use of Animal Models for the Study of Fetal Alcohol Spectrum Disorders |
title_sort | focus on: the use of animal models for the study of fetal alcohol spectrum disorders |
topic | Update on Animal Models |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625987/ https://www.ncbi.nlm.nih.gov/pubmed/23580046 |
work_keys_str_mv | AT wilsonshannone focusontheuseofanimalmodelsforthestudyoffetalalcoholspectrumdisorders AT cuddtimothya focusontheuseofanimalmodelsforthestudyoffetalalcoholspectrumdisorders |