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Expression of Inflammation-Related Genes Is Altered in Gastric Tissue of Patients with Advanced Stages of NAFLD

Obesity is associated with chronic low-grade inflammation perpetuated by visceral adipose. Other organs, particularly stomach and intestine, may also overproduce proinflammatory molecules. We examined the gene expression patterns in gastric tissue of morbidly obese patients with nonalcoholic fatty l...

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Autores principales: Mehta, Rohini, Birerdinc, Aybike, Neupane, Arpan, Shamsaddini, Amirhossein, Afendy, Arian, Elariny, Hazem, Chandhoke, Vikas, Baranova, Ancha, Younossi, Zobair M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626032/
https://www.ncbi.nlm.nih.gov/pubmed/23661906
http://dx.doi.org/10.1155/2013/684237
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author Mehta, Rohini
Birerdinc, Aybike
Neupane, Arpan
Shamsaddini, Amirhossein
Afendy, Arian
Elariny, Hazem
Chandhoke, Vikas
Baranova, Ancha
Younossi, Zobair M.
author_facet Mehta, Rohini
Birerdinc, Aybike
Neupane, Arpan
Shamsaddini, Amirhossein
Afendy, Arian
Elariny, Hazem
Chandhoke, Vikas
Baranova, Ancha
Younossi, Zobair M.
author_sort Mehta, Rohini
collection PubMed
description Obesity is associated with chronic low-grade inflammation perpetuated by visceral adipose. Other organs, particularly stomach and intestine, may also overproduce proinflammatory molecules. We examined the gene expression patterns in gastric tissue of morbidly obese patients with nonalcoholic fatty liver disease (NAFLD) and compared the changes in gene expression in different histological forms of NAFLD. Stomach tissue samples from 20 morbidly obese NAFLD patients who were undergoing sleeve gastrectomy were profiled using qPCR for 84 genes encoding inflammatory cytokines, chemokines, their receptors, and other components of inflammatory cascades. Interleukin 8 receptor-beta (IL8RB) gene overexpression in gastric tissue was correlated with the presence of hepatic steatosis, hepatic fibrosis, and histologic diagnosis of nonalcoholic steatohepatitis (NASH). Expression levels of soluble interleukin 1 receptor antagonist (IL1RN) were correlated with the presence of NASH and hepatic fibrosis. mRNA levels of interleukin 8 (IL8), chemokine (C-C motif) ligand 4 (CCL4), and its receptor chemokine (C-C motif) receptor type 5 (CCR5) showed a significant increase in patients with advanced hepatic inflammation and were correlated with the severity of the hepatic inflammation. The results of our study suggest that changes in expression patterns for inflammatory molecule encoding genes within gastric tissue may contribute to the pathogenesis of obesity-related NAFLD.
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spelling pubmed-36260322013-05-09 Expression of Inflammation-Related Genes Is Altered in Gastric Tissue of Patients with Advanced Stages of NAFLD Mehta, Rohini Birerdinc, Aybike Neupane, Arpan Shamsaddini, Amirhossein Afendy, Arian Elariny, Hazem Chandhoke, Vikas Baranova, Ancha Younossi, Zobair M. Mediators Inflamm Clinical Study Obesity is associated with chronic low-grade inflammation perpetuated by visceral adipose. Other organs, particularly stomach and intestine, may also overproduce proinflammatory molecules. We examined the gene expression patterns in gastric tissue of morbidly obese patients with nonalcoholic fatty liver disease (NAFLD) and compared the changes in gene expression in different histological forms of NAFLD. Stomach tissue samples from 20 morbidly obese NAFLD patients who were undergoing sleeve gastrectomy were profiled using qPCR for 84 genes encoding inflammatory cytokines, chemokines, their receptors, and other components of inflammatory cascades. Interleukin 8 receptor-beta (IL8RB) gene overexpression in gastric tissue was correlated with the presence of hepatic steatosis, hepatic fibrosis, and histologic diagnosis of nonalcoholic steatohepatitis (NASH). Expression levels of soluble interleukin 1 receptor antagonist (IL1RN) were correlated with the presence of NASH and hepatic fibrosis. mRNA levels of interleukin 8 (IL8), chemokine (C-C motif) ligand 4 (CCL4), and its receptor chemokine (C-C motif) receptor type 5 (CCR5) showed a significant increase in patients with advanced hepatic inflammation and were correlated with the severity of the hepatic inflammation. The results of our study suggest that changes in expression patterns for inflammatory molecule encoding genes within gastric tissue may contribute to the pathogenesis of obesity-related NAFLD. Hindawi Publishing Corporation 2013 2013-03-30 /pmc/articles/PMC3626032/ /pubmed/23661906 http://dx.doi.org/10.1155/2013/684237 Text en Copyright © 2013 Rohini Mehta et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Mehta, Rohini
Birerdinc, Aybike
Neupane, Arpan
Shamsaddini, Amirhossein
Afendy, Arian
Elariny, Hazem
Chandhoke, Vikas
Baranova, Ancha
Younossi, Zobair M.
Expression of Inflammation-Related Genes Is Altered in Gastric Tissue of Patients with Advanced Stages of NAFLD
title Expression of Inflammation-Related Genes Is Altered in Gastric Tissue of Patients with Advanced Stages of NAFLD
title_full Expression of Inflammation-Related Genes Is Altered in Gastric Tissue of Patients with Advanced Stages of NAFLD
title_fullStr Expression of Inflammation-Related Genes Is Altered in Gastric Tissue of Patients with Advanced Stages of NAFLD
title_full_unstemmed Expression of Inflammation-Related Genes Is Altered in Gastric Tissue of Patients with Advanced Stages of NAFLD
title_short Expression of Inflammation-Related Genes Is Altered in Gastric Tissue of Patients with Advanced Stages of NAFLD
title_sort expression of inflammation-related genes is altered in gastric tissue of patients with advanced stages of nafld
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626032/
https://www.ncbi.nlm.nih.gov/pubmed/23661906
http://dx.doi.org/10.1155/2013/684237
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