Biological functions of natural antisense transcripts

In theory, the human genome is large enough to keep its roughly 20,000 genes well separated. In practice, genes are clustered; even more puzzling, in many cases both DNA strands of a protein coding gene are transcribed. The resulting natural antisense transcripts can be a blessing and curse, as many...

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Detalles Bibliográficos
Autor principal: Werner, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626547/
https://www.ncbi.nlm.nih.gov/pubmed/23577602
http://dx.doi.org/10.1186/1741-7007-11-31
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author Werner, Andreas
author_facet Werner, Andreas
author_sort Werner, Andreas
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description In theory, the human genome is large enough to keep its roughly 20,000 genes well separated. In practice, genes are clustered; even more puzzling, in many cases both DNA strands of a protein coding gene are transcribed. The resulting natural antisense transcripts can be a blessing and curse, as many appreciate, or simply transcriptional trash, as others believe. Widespread evolutionary conservation, as recently demonstrated, is a good indicator for potential biological functions of natural antisense transcripts. See research article: http://www.biomedcentral.com/1471-2164/14/243
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spelling pubmed-36265472013-04-16 Biological functions of natural antisense transcripts Werner, Andreas BMC Biol Commentary In theory, the human genome is large enough to keep its roughly 20,000 genes well separated. In practice, genes are clustered; even more puzzling, in many cases both DNA strands of a protein coding gene are transcribed. The resulting natural antisense transcripts can be a blessing and curse, as many appreciate, or simply transcriptional trash, as others believe. Widespread evolutionary conservation, as recently demonstrated, is a good indicator for potential biological functions of natural antisense transcripts. See research article: http://www.biomedcentral.com/1471-2164/14/243 BioMed Central 2013-04-12 /pmc/articles/PMC3626547/ /pubmed/23577602 http://dx.doi.org/10.1186/1741-7007-11-31 Text en Copyright © 2013 Werner; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Werner, Andreas
Biological functions of natural antisense transcripts
title Biological functions of natural antisense transcripts
title_full Biological functions of natural antisense transcripts
title_fullStr Biological functions of natural antisense transcripts
title_full_unstemmed Biological functions of natural antisense transcripts
title_short Biological functions of natural antisense transcripts
title_sort biological functions of natural antisense transcripts
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626547/
https://www.ncbi.nlm.nih.gov/pubmed/23577602
http://dx.doi.org/10.1186/1741-7007-11-31
work_keys_str_mv AT wernerandreas biologicalfunctionsofnaturalantisensetranscripts

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