MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1

BACKGROUND: Neuroblastoma is responsible for 15% of all childhood cancer deaths. Despite advances in treatment and disease management, the overall 5-year survival rates remain poor in high-risk disease (25-40%). MiR-497 was previously identified by our laboratory as a member of a miRNA expression si...

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Detalles Bibliográficos
Autores principales: Creevey, Laura, Ryan, Jacqueline, Harvey, Harry, Bray, Isabella M, Meehan, Maria, Khan, Adnan R, Stallings, Raymond L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626575/
https://www.ncbi.nlm.nih.gov/pubmed/23531080
http://dx.doi.org/10.1186/1476-4598-12-23

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