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HIV restriction in quiescent CD4(+) T cells

The restriction of the Human Immunodeficiency Virus (HIV) infection in quiescent CD4(+) T cells has been an area of active investigation. Early studies have suggested that this T cell subset is refractory to infection by the virus. Subsequently it was demonstrated that quiescent cells could be infec...

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Detalles Bibliográficos
Autores principales: Zack, Jerome A, Kim, Sohn G, Vatakis, Dimitrios N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626626/
https://www.ncbi.nlm.nih.gov/pubmed/23557201
http://dx.doi.org/10.1186/1742-4690-10-37
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author Zack, Jerome A
Kim, Sohn G
Vatakis, Dimitrios N
author_facet Zack, Jerome A
Kim, Sohn G
Vatakis, Dimitrios N
author_sort Zack, Jerome A
collection PubMed
description The restriction of the Human Immunodeficiency Virus (HIV) infection in quiescent CD4(+) T cells has been an area of active investigation. Early studies have suggested that this T cell subset is refractory to infection by the virus. Subsequently it was demonstrated that quiescent cells could be infected at low levels; nevertheless these observations supported the earlier assertions of debilitating defects in the viral life cycle. This phenomenon raised hopes that identification of the block in quiescent cells could lead to the development of new therapies against HIV. As limiting levels of raw cellular factors such as nucleotides did not account for the block to infection, a number of groups pursued the identification of cellular proteins whose presence or absence may impact the permissiveness of quiescent T cells to HIV infection. A series of studies in the past few years have identified a number of host factors implicated in the block to infection. In this review, we will present the progress made, other avenues of investigation and the potential impact these studies have in the development of more effective therapies against HIV.
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spelling pubmed-36266262013-04-16 HIV restriction in quiescent CD4(+) T cells Zack, Jerome A Kim, Sohn G Vatakis, Dimitrios N Retrovirology Review The restriction of the Human Immunodeficiency Virus (HIV) infection in quiescent CD4(+) T cells has been an area of active investigation. Early studies have suggested that this T cell subset is refractory to infection by the virus. Subsequently it was demonstrated that quiescent cells could be infected at low levels; nevertheless these observations supported the earlier assertions of debilitating defects in the viral life cycle. This phenomenon raised hopes that identification of the block in quiescent cells could lead to the development of new therapies against HIV. As limiting levels of raw cellular factors such as nucleotides did not account for the block to infection, a number of groups pursued the identification of cellular proteins whose presence or absence may impact the permissiveness of quiescent T cells to HIV infection. A series of studies in the past few years have identified a number of host factors implicated in the block to infection. In this review, we will present the progress made, other avenues of investigation and the potential impact these studies have in the development of more effective therapies against HIV. BioMed Central 2013-04-04 /pmc/articles/PMC3626626/ /pubmed/23557201 http://dx.doi.org/10.1186/1742-4690-10-37 Text en Copyright © 2013 Zack et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Zack, Jerome A
Kim, Sohn G
Vatakis, Dimitrios N
HIV restriction in quiescent CD4(+) T cells
title HIV restriction in quiescent CD4(+) T cells
title_full HIV restriction in quiescent CD4(+) T cells
title_fullStr HIV restriction in quiescent CD4(+) T cells
title_full_unstemmed HIV restriction in quiescent CD4(+) T cells
title_short HIV restriction in quiescent CD4(+) T cells
title_sort hiv restriction in quiescent cd4(+) t cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626626/
https://www.ncbi.nlm.nih.gov/pubmed/23557201
http://dx.doi.org/10.1186/1742-4690-10-37
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