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Generation and in vivo characterization of a chimeric α(v)β(5)-targeting antibody 14C5 and its derivatives

BACKGROUND: Previous studies showed that radiolabeled murine monoclonal antibody (mAb) 14C5 and its Fab and F(ab')(2) fragments, targeting α(v)β(5) integrin, have promising properties for diagnostic and therapeutic applications in cancer. To diminish the risk of generating a human anti-mouse an...

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Detalles Bibliográficos
Autores principales:	Dumolyn, Caroline, Schoonooghe, Steve, Moerman, Lieselotte, Neyt, Sara, Haustraete, Jurgen, De Vos, Filip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626673/ https://www.ncbi.nlm.nih.gov/pubmed/23557246 http://dx.doi.org/10.1186/2191-219X-3-25

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