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Side chain requirements for affinity and specificity in D5, an HIV-1 antibody derived from the V(H)1-69 germline segment

BACKGROUND: Analysis of factors contributing to high affinity antibody-protein interactions provides insight into natural antibody evolution, and guides the design of antibodies with new or enhanced function. We previously studied the interaction between antibody D5 and its target, a designed protei...

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Detalles Bibliográficos
Autores principales:	Stewart, Alex, Harrison, Joseph S, Regula, Lauren K, Lai, Jonathan R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626704/ https://www.ncbi.nlm.nih.gov/pubmed/23566198 http://dx.doi.org/10.1186/1471-2091-14-9

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