Glucose-methanol co-utilization in Pichia pastoris studied by metabolomics and instationary (13)C flux analysis

BACKGROUND: Several studies have shown that the utilization of mixed carbon feeds instead of methanol as sole carbon source is beneficial for protein production with the methylotrophic yeast Pichia pastoris. In particular, growth under mixed feed conditions appears to alleviate the metabolic burden...

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Detalles Bibliográficos
Autores principales: Jordà, Joel, Suarez, Camilo, Carnicer, Marc, ten Pierick, Angela, Heijnen, Joseph J, van Gulik, Walter, Ferrer, Pau, Albiol, Joan, Wahl, Aljoscha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626722/
https://www.ncbi.nlm.nih.gov/pubmed/23448228
http://dx.doi.org/10.1186/1752-0509-7-17

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