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Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain

BACKGROUND: GTP cyclohydrolase 1 (GTP-CH1), the rate-limiting enzyme in the synthesis of tetrahydrobiopterin (BH4), encoded by the GCH1 gene, has been implicated in the development and maintenance of inflammatory pain in rats. In humans, homozygous carriers of a “pain-protective” (PP) haplotype of t...

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Detalles Bibliográficos
Autores principales:	Nasser, Arafat, Bjerrum, Ole J, Heegaard, Anne-Marie, Møller, Anette T, Larsen, Majbritt, Dalbøge, Louise S, Dupont, Erik, Jensen, Troels S, Møller, Lisbeth B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626862/ https://www.ncbi.nlm.nih.gov/pubmed/23421753 http://dx.doi.org/10.1186/1744-8069-9-5

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