Profound hyperacute cardiac allograft rejection rescue with biventricular mechanical circulatory support and plasmapheresis, intravenous immunoglobulin, and rituximab therapy

Hyperacute rejection is a rare but potentially catastrophic complication after cardiac transplantation. We describe an unusual case of hyperacute rejection due to preformed anti-donor antibodies despite a negative preoperative panel-reactive antibody (PRA) screen. An excellent outcome was achieved i...

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Autores principales: Kaczorowski, David J, Datta, Jashodeep, Kamoun, Malek, Dries, Daniel L, Woo, Y Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626898/
https://www.ncbi.nlm.nih.gov/pubmed/23497431
http://dx.doi.org/10.1186/1749-8090-8-48
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author Kaczorowski, David J
Datta, Jashodeep
Kamoun, Malek
Dries, Daniel L
Woo, Y Joseph
author_facet Kaczorowski, David J
Datta, Jashodeep
Kamoun, Malek
Dries, Daniel L
Woo, Y Joseph
author_sort Kaczorowski, David J
collection PubMed
description Hyperacute rejection is a rare but potentially catastrophic complication after cardiac transplantation. We describe an unusual case of hyperacute rejection due to preformed anti-donor antibodies despite a negative preoperative panel-reactive antibody (PRA) screen. An excellent outcome was achieved in this case and our strategy involving the use of CentriMag ventricular assist devices (VADs) for biventricular support during treatment with rituximab, intravenous immunoglobulin (IVIG), and plasmapheresis is illustrated.
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spelling pubmed-36268982013-04-17 Profound hyperacute cardiac allograft rejection rescue with biventricular mechanical circulatory support and plasmapheresis, intravenous immunoglobulin, and rituximab therapy Kaczorowski, David J Datta, Jashodeep Kamoun, Malek Dries, Daniel L Woo, Y Joseph J Cardiothorac Surg Case Report Hyperacute rejection is a rare but potentially catastrophic complication after cardiac transplantation. We describe an unusual case of hyperacute rejection due to preformed anti-donor antibodies despite a negative preoperative panel-reactive antibody (PRA) screen. An excellent outcome was achieved in this case and our strategy involving the use of CentriMag ventricular assist devices (VADs) for biventricular support during treatment with rituximab, intravenous immunoglobulin (IVIG), and plasmapheresis is illustrated. BioMed Central 2013-03-16 /pmc/articles/PMC3626898/ /pubmed/23497431 http://dx.doi.org/10.1186/1749-8090-8-48 Text en Copyright © 2013 Kaczorowski et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kaczorowski, David J
Datta, Jashodeep
Kamoun, Malek
Dries, Daniel L
Woo, Y Joseph
Profound hyperacute cardiac allograft rejection rescue with biventricular mechanical circulatory support and plasmapheresis, intravenous immunoglobulin, and rituximab therapy
title Profound hyperacute cardiac allograft rejection rescue with biventricular mechanical circulatory support and plasmapheresis, intravenous immunoglobulin, and rituximab therapy
title_full Profound hyperacute cardiac allograft rejection rescue with biventricular mechanical circulatory support and plasmapheresis, intravenous immunoglobulin, and rituximab therapy
title_fullStr Profound hyperacute cardiac allograft rejection rescue with biventricular mechanical circulatory support and plasmapheresis, intravenous immunoglobulin, and rituximab therapy
title_full_unstemmed Profound hyperacute cardiac allograft rejection rescue with biventricular mechanical circulatory support and plasmapheresis, intravenous immunoglobulin, and rituximab therapy
title_short Profound hyperacute cardiac allograft rejection rescue with biventricular mechanical circulatory support and plasmapheresis, intravenous immunoglobulin, and rituximab therapy
title_sort profound hyperacute cardiac allograft rejection rescue with biventricular mechanical circulatory support and plasmapheresis, intravenous immunoglobulin, and rituximab therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626898/
https://www.ncbi.nlm.nih.gov/pubmed/23497431
http://dx.doi.org/10.1186/1749-8090-8-48
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