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Z-disc Transcriptional Coupling, Sarcomeroptosis and Mechanopoptosis

Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. Heart failure, which contributes significantly to the incidence and prevalence of cardiovascular-related diseases, can be the result of a myriad of diverse aetiologies including viral infections, coronary heart disea...

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Detalles Bibliográficos
Autores principales: Knöll, Ralph, Buyandelger, Byambajav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627051/
https://www.ncbi.nlm.nih.gov/pubmed/23065501
http://dx.doi.org/10.1007/s12013-012-9430-6
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author Knöll, Ralph
Buyandelger, Byambajav
author_facet Knöll, Ralph
Buyandelger, Byambajav
author_sort Knöll, Ralph
collection PubMed
description Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. Heart failure, which contributes significantly to the incidence and prevalence of cardiovascular-related diseases, can be the result of a myriad of diverse aetiologies including viral infections, coronary heart disease and genetic abnormalities—just to name a few. Interestingly, almost every type of heart failure is characterized by the loss of cardiac myocytes, either via necrosis, apoptosis or autophagy. While the former for a long time mainly has been characterized by passive loss of cells and only the latter two have been regarded as active processes, a new view is now emerging, whereby all three forms of cell death are regarded as different types of programmed cell death which can be induced via different stimuli and pathways, most of which are probably not well understood (Kung et al., Circulation Research 108(8):1017–1036, 2011). Here, we focus on the sarcomeric Z-disc, Z-disc transcriptional coupling and its role in pro-survival pathways as well as in striated muscle specific forms of cell death (sarcomeroptosis) and mechanically induced apoptosis or mechanoptosis.
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spelling pubmed-36270512013-04-17 Z-disc Transcriptional Coupling, Sarcomeroptosis and Mechanopoptosis Knöll, Ralph Buyandelger, Byambajav Cell Biochem Biophys Original Paper Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. Heart failure, which contributes significantly to the incidence and prevalence of cardiovascular-related diseases, can be the result of a myriad of diverse aetiologies including viral infections, coronary heart disease and genetic abnormalities—just to name a few. Interestingly, almost every type of heart failure is characterized by the loss of cardiac myocytes, either via necrosis, apoptosis or autophagy. While the former for a long time mainly has been characterized by passive loss of cells and only the latter two have been regarded as active processes, a new view is now emerging, whereby all three forms of cell death are regarded as different types of programmed cell death which can be induced via different stimuli and pathways, most of which are probably not well understood (Kung et al., Circulation Research 108(8):1017–1036, 2011). Here, we focus on the sarcomeric Z-disc, Z-disc transcriptional coupling and its role in pro-survival pathways as well as in striated muscle specific forms of cell death (sarcomeroptosis) and mechanically induced apoptosis or mechanoptosis. Springer-Verlag 2012-10-14 2013 /pmc/articles/PMC3627051/ /pubmed/23065501 http://dx.doi.org/10.1007/s12013-012-9430-6 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Paper
Knöll, Ralph
Buyandelger, Byambajav
Z-disc Transcriptional Coupling, Sarcomeroptosis and Mechanopoptosis
title Z-disc Transcriptional Coupling, Sarcomeroptosis and Mechanopoptosis
title_full Z-disc Transcriptional Coupling, Sarcomeroptosis and Mechanopoptosis
title_fullStr Z-disc Transcriptional Coupling, Sarcomeroptosis and Mechanopoptosis
title_full_unstemmed Z-disc Transcriptional Coupling, Sarcomeroptosis and Mechanopoptosis
title_short Z-disc Transcriptional Coupling, Sarcomeroptosis and Mechanopoptosis
title_sort z-disc transcriptional coupling, sarcomeroptosis and mechanopoptosis
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627051/
https://www.ncbi.nlm.nih.gov/pubmed/23065501
http://dx.doi.org/10.1007/s12013-012-9430-6
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