Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking

Kruppel-like factor 5 (Klf5) regulates pluripotent stem cell self-renewal but its role in somatic stem cells is unknown. Here we show that Klf5 deficient haematopoietic stem cells and progenitors (HSC/P) fail to engraft after transplantation. This HSC/P defect is associated with impaired bone marrow...

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Detalles Bibliográficos
Autores principales: Taniguchi Ishikawa, E., Chang, K.H., Nayak, R., Olsson, H.A, Ficker, A., Dunn, S.K., Madhu, M., Sengupta, A., Whitsett, J.A., Grimes, H.L., Cancelas, J.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627399/
https://www.ncbi.nlm.nih.gov/pubmed/23552075
http://dx.doi.org/10.1038/ncomms2645

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