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Defining MC1R Regulation in Human Melanocytes by Its Agonist α-Melanocortin and Antagonists Agouti Signaling Protein and β-Defensin 3

The melanocortin 1 receptor (MC1R), a G(s) protein-coupled receptor, plays an important role in human pigmentation. We investigated the regulation of expression and activity of the MC1R in primary human melanocyte cultures. Human beta defensin 3 (HBD3) acted as an antagonist for MC1R, inhibiting the...

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Detalles Bibliográficos
Autores principales:	Swope, Viki, Jameson, Joshua, McFarland, Kevin, Supp, Dorothy, Miller, William, McGraw, Dennis, Patel, Mira A., Nix, Matthew A., Milhauser, Glenn, Babcock, George, Abdel-Malek, Zalfa A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627493/ https://www.ncbi.nlm.nih.gov/pubmed/22572817 http://dx.doi.org/10.1038/jid.2012.135

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