Functional DNA demethylation is accompanied by chromatin accessibility

DNA methylation inhibitors such as 5-aza-2′-deoxycytidine (5-Aza-CdR) are currently used for the treatment of myelodysplastic syndrome. Although global DNA demethylation has been observed after treatment, it is unclear to what extent demethylation induces changes in nucleosome occupancy, a key deter...

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Detalles Bibliográficos
Autores principales: Pandiyan, Kurinji, You, Jueng Soo, Yang, Xiaojing, Dai, Chao, Zhou, Xianghong J., Baylin, Stephen B., Jones, Peter A., Liang, Gangning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627572/
https://www.ncbi.nlm.nih.gov/pubmed/23408854
http://dx.doi.org/10.1093/nar/gkt077

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