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Novel inhibition of archaeal family-D DNA polymerase by uracil

Archaeal family-D DNA polymerase is inhibited by the presence of uracil in DNA template strands. When the enzyme encounters uracil, following three parameters change: DNA binding increases roughly 2-fold, the rate of polymerization slows by a factor of ∼5 and 3′–5′ proof-reading exonuclease activity...

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Detalles Bibliográficos
Autores principales:	Richardson, Tomas T., Gilroy, Louise, Ishino, Yoshizumi, Connolly, Bernard A., Henneke, Ghislaine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627576/ https://www.ncbi.nlm.nih.gov/pubmed/23408858 http://dx.doi.org/10.1093/nar/gkt083

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