Dual functional BAFF receptor aptamers inhibit ligand-induced proliferation and deliver siRNAs to NHL cells

The B-cell–activating factor (BAFF)-receptor (BAFF-R) is restrictedly expressed on B-cells and is often overexpressed in B-cell malignancies, such as non-Hodgkin’s lymphoma. On binding to its ligand BAFF, proliferation and cell survival are increased, enabling cancer cells to proliferate faster than...

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Detalles Bibliográficos
Autores principales: Zhou, Jiehua, Tiemann, Katrin, Chomchan, Pritsana, Alluin, Jessica, Swiderski, Piotr, Burnett, John, Zhang, Xizhe, Forman, Stephen, Chen, Robert, Rossi, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627597/
https://www.ncbi.nlm.nih.gov/pubmed/23470998
http://dx.doi.org/10.1093/nar/gkt125

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