Active regulator of SIRT1 is required for ribosome biogenesis and function

Active regulator of SIRT1 (AROS) binds and upregulates SIRT1, an NAD(+)-dependent deacetylase. In addition, AROS binds RPS19, a structural ribosomal protein, which also functions in ribosome biogenesis and is implicated in multiple disease states. The significance of AROS in relation to ribosome bio...

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Detalles Bibliográficos
Autores principales: Knight, John R. P., Willis, Anne E., Milner, Jo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627601/
https://www.ncbi.nlm.nih.gov/pubmed/23462953
http://dx.doi.org/10.1093/nar/gkt129

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