Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation

The eukaryotic DNA replication initiation factor Mcm10 is essential for both replisome assembly and function. Human Mcm10 has two DNA-binding domains, the conserved internal domain (ID) and the C-terminal domain (CTD), which is specific to metazoans. SIRT1 is a nicotinamide adenine dinucleotide (NAD...

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Detalles Bibliográficos
Autores principales: Fatoba, Samuel T., Tognetti, Silvia, Berto, Melissa, Leo, Elisabetta, Mulvey, Claire M., Godovac-Zimmermann, Jasminka, Pommier, Yves, Okorokov, Andrei L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627603/
https://www.ncbi.nlm.nih.gov/pubmed/23449222
http://dx.doi.org/10.1093/nar/gkt131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627603/
https://www.ncbi.nlm.nih.gov/pubmed/23449222
http://dx.doi.org/10.1093/nar/gkt131

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