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Potential role of N-carbamoyl glutamate in biosynthesis of arginine and its significance in production of ruminant animals
Arginine (ARG) exerts many beneficial effects on animal body and enhanced angiogenesis, lactogenesis, which finally leads to the improvement in nitrogen (N) metabolism, reproduction, lactation, immunity and growth. Unfortunately, unprotected ARG will be degraded in the rumen and its price is high, t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627613/ https://www.ncbi.nlm.nih.gov/pubmed/23575433 http://dx.doi.org/10.1186/2049-1891-4-16 |
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author | Chacher, Bahram Liu, Hongyun Wang, Diming Liu, Jianxin |
author_facet | Chacher, Bahram Liu, Hongyun Wang, Diming Liu, Jianxin |
author_sort | Chacher, Bahram |
collection | PubMed |
description | Arginine (ARG) exerts many beneficial effects on animal body and enhanced angiogenesis, lactogenesis, which finally leads to the improvement in nitrogen (N) metabolism, reproduction, lactation, immunity and growth. Unfortunately, unprotected ARG will be degraded in the rumen and its price is high, thus feeding rumen-protected ARG seems to be uneconomical. Alternatively, N-carbamoyl glutamate (NCG) is structural analogue of N-acetyl glutamate, cofactor of cabamoyl phosphate synthetase1, is lower in rumen degradation compared to ARG. Additionally, rumen epithelial and duodenal cells have potentially utilized the NCG for ureagenesis. Supplementation of NCG to high yielding dairy cows increased plasma concentration of ARG and nitric oxide, decreased the plasma ammonia N and improved lactation performance and N utilization. Supplementation of NCG enhanced pregnancy rates in rats, improved litter size and fetal survival rate, thereby improved the reproductive performance of sows. Oral NCG supplementation increases plasma ARG and somatotropin levels, and increased growth rate and muscle protein synthesis in nursing piglets. The NCG is potential a relatively cheaper source of feed additive to offer vital compensation over oral administration of ARG, resulting in improved ruminant animal health and production. In this article, we reviewed the mechanism of ARG biosynthesis by NCG and their significance in growth, reproduction, milk production and N utilization in ruminant animals. |
format | Online Article Text |
id | pubmed-3627613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36276132013-04-18 Potential role of N-carbamoyl glutamate in biosynthesis of arginine and its significance in production of ruminant animals Chacher, Bahram Liu, Hongyun Wang, Diming Liu, Jianxin J Anim Sci Biotechnol Review Arginine (ARG) exerts many beneficial effects on animal body and enhanced angiogenesis, lactogenesis, which finally leads to the improvement in nitrogen (N) metabolism, reproduction, lactation, immunity and growth. Unfortunately, unprotected ARG will be degraded in the rumen and its price is high, thus feeding rumen-protected ARG seems to be uneconomical. Alternatively, N-carbamoyl glutamate (NCG) is structural analogue of N-acetyl glutamate, cofactor of cabamoyl phosphate synthetase1, is lower in rumen degradation compared to ARG. Additionally, rumen epithelial and duodenal cells have potentially utilized the NCG for ureagenesis. Supplementation of NCG to high yielding dairy cows increased plasma concentration of ARG and nitric oxide, decreased the plasma ammonia N and improved lactation performance and N utilization. Supplementation of NCG enhanced pregnancy rates in rats, improved litter size and fetal survival rate, thereby improved the reproductive performance of sows. Oral NCG supplementation increases plasma ARG and somatotropin levels, and increased growth rate and muscle protein synthesis in nursing piglets. The NCG is potential a relatively cheaper source of feed additive to offer vital compensation over oral administration of ARG, resulting in improved ruminant animal health and production. In this article, we reviewed the mechanism of ARG biosynthesis by NCG and their significance in growth, reproduction, milk production and N utilization in ruminant animals. BioMed Central 2013-04-10 /pmc/articles/PMC3627613/ /pubmed/23575433 http://dx.doi.org/10.1186/2049-1891-4-16 Text en Copyright © 2013 Chacher et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Chacher, Bahram Liu, Hongyun Wang, Diming Liu, Jianxin Potential role of N-carbamoyl glutamate in biosynthesis of arginine and its significance in production of ruminant animals |
title | Potential role of N-carbamoyl glutamate in biosynthesis of arginine and its significance in production of ruminant animals |
title_full | Potential role of N-carbamoyl glutamate in biosynthesis of arginine and its significance in production of ruminant animals |
title_fullStr | Potential role of N-carbamoyl glutamate in biosynthesis of arginine and its significance in production of ruminant animals |
title_full_unstemmed | Potential role of N-carbamoyl glutamate in biosynthesis of arginine and its significance in production of ruminant animals |
title_short | Potential role of N-carbamoyl glutamate in biosynthesis of arginine and its significance in production of ruminant animals |
title_sort | potential role of n-carbamoyl glutamate in biosynthesis of arginine and its significance in production of ruminant animals |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627613/ https://www.ncbi.nlm.nih.gov/pubmed/23575433 http://dx.doi.org/10.1186/2049-1891-4-16 |
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