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Association between T174M polymorphism in the angiotensinogen gene and risk of coronary artery disease: a meta-analysis

BACKGROUND: Angiotensinogen (AGT) T174M gene polymorphism has been suggested to be linked to risk of coronary artery disease, however, results from studies of this association have been inconsistent. In this study, we assess the relationship between AGT T174M gene polymorphism and coronary artery di...

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Autor principal: Wang, Wen-Zhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627715/
https://www.ncbi.nlm.nih.gov/pubmed/23610575
http://dx.doi.org/10.3969/j.issn.1671-5411.2013.01.010
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author Wang, Wen-Zhu
author_facet Wang, Wen-Zhu
author_sort Wang, Wen-Zhu
collection PubMed
description BACKGROUND: Angiotensinogen (AGT) T174M gene polymorphism has been suggested to be linked to risk of coronary artery disease, however, results from studies of this association have been inconsistent. In this study, we assess the relationship between AGT T174M gene polymorphism and coronary artery disease. METHODS: We conducted a meta-analysis of 18 case-control studies with 8,147 coronary artery disease cases and 5,344 controls in Google scholar, PubMed, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases to identify eligible studies published by July, 2012. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated from these studies. RESULTS: Overall, a significant association was found between angiotensinogen T174M polymorphism and coronary artery disease risk when all studies were pooled into the meta-analysis (TT vs. MM: OR = 0.53, 95% CI = 0.40–0.71; dominant model: OR = 1.16, 95% CI = 1.01–1.35; recessive model: OR = 0.54, 95% CI = 0.40–0.72). In a stratified analysis, the results indicate a significant association in Caucasians suffering from coronary stenosis (TT vs. MM: OR = 0.38, 95% CI = 0.23–0.63; recessive model: OR = 0.39, 95% CI = 0.23–0.64). No significant increased risk for coronary artery disease was found in Asians. CONCLUSIONS: The meta-analysis indicate a significant association of T174M polymorphism with coronary stenosis risk in Caucasians.
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spelling pubmed-36277152013-04-22 Association between T174M polymorphism in the angiotensinogen gene and risk of coronary artery disease: a meta-analysis Wang, Wen-Zhu J Geriatr Cardiol Research Article BACKGROUND: Angiotensinogen (AGT) T174M gene polymorphism has been suggested to be linked to risk of coronary artery disease, however, results from studies of this association have been inconsistent. In this study, we assess the relationship between AGT T174M gene polymorphism and coronary artery disease. METHODS: We conducted a meta-analysis of 18 case-control studies with 8,147 coronary artery disease cases and 5,344 controls in Google scholar, PubMed, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases to identify eligible studies published by July, 2012. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated from these studies. RESULTS: Overall, a significant association was found between angiotensinogen T174M polymorphism and coronary artery disease risk when all studies were pooled into the meta-analysis (TT vs. MM: OR = 0.53, 95% CI = 0.40–0.71; dominant model: OR = 1.16, 95% CI = 1.01–1.35; recessive model: OR = 0.54, 95% CI = 0.40–0.72). In a stratified analysis, the results indicate a significant association in Caucasians suffering from coronary stenosis (TT vs. MM: OR = 0.38, 95% CI = 0.23–0.63; recessive model: OR = 0.39, 95% CI = 0.23–0.64). No significant increased risk for coronary artery disease was found in Asians. CONCLUSIONS: The meta-analysis indicate a significant association of T174M polymorphism with coronary stenosis risk in Caucasians. Science Press 2013-03 /pmc/articles/PMC3627715/ /pubmed/23610575 http://dx.doi.org/10.3969/j.issn.1671-5411.2013.01.010 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Research Article
Wang, Wen-Zhu
Association between T174M polymorphism in the angiotensinogen gene and risk of coronary artery disease: a meta-analysis
title Association between T174M polymorphism in the angiotensinogen gene and risk of coronary artery disease: a meta-analysis
title_full Association between T174M polymorphism in the angiotensinogen gene and risk of coronary artery disease: a meta-analysis
title_fullStr Association between T174M polymorphism in the angiotensinogen gene and risk of coronary artery disease: a meta-analysis
title_full_unstemmed Association between T174M polymorphism in the angiotensinogen gene and risk of coronary artery disease: a meta-analysis
title_short Association between T174M polymorphism in the angiotensinogen gene and risk of coronary artery disease: a meta-analysis
title_sort association between t174m polymorphism in the angiotensinogen gene and risk of coronary artery disease: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627715/
https://www.ncbi.nlm.nih.gov/pubmed/23610575
http://dx.doi.org/10.3969/j.issn.1671-5411.2013.01.010
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