Lis1 controls dynamics of neuronal filopodia and spines to impact synaptogenesis and social behaviour

LIS1 (PAFAH1B1) mutation can impair neuronal migration, causing lissencephaly in humans. LIS1 loss is associated with dynein protein motor dysfunction, and disrupts the actin cytoskeleton through disregulated RhoGTPases. Recently, LIS1 was implicated as an important protein-network interaction node...

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Detalles Bibliográficos
Autores principales: Sudarov, Anamaria, Gooden, Frank, Tseng, Debbie, Gan, Wen-Biao, Ross, Margaret Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628102/
https://www.ncbi.nlm.nih.gov/pubmed/23483716
http://dx.doi.org/10.1002/emmm.201202106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628102/
https://www.ncbi.nlm.nih.gov/pubmed/23483716
http://dx.doi.org/10.1002/emmm.201202106

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