Cargando…

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

The insulin/insulin-like growth factor-1 signalling (IIS) pathway regulates cellular and organismal metabolism and controls the rate of aging. Gain-of-function mutations in p110α, the principal mammalian IIS-responsive isoform of PI 3-kinase (PI3K), promote cancer. In contrast, loss-of-function muta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Foukas, Lazaros C, Bilanges, Benoit, Bettedi, Lucia, Pearce, Wayne, Ali, Khaled, Sancho, Sara, Withers, Dominic J, Vanhaesebroeck, Bart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628103/ https://www.ncbi.nlm.nih.gov/pubmed/23483710 http://dx.doi.org/10.1002/emmm.201201953

Ejemplares similares

Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice
por: Alliouachene, Samira, et al.
Publicado: (2016)

Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
por: Araiz, Caroline, et al.
Publicado: (2019)

Publisher Correction: Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
por: Araiz, Caroline, et al.
Publicado: (2020)

Increased mitochondrial and lipid metabolism is a conserved effect of Insulin/PI3K pathway downregulation in adipose tissue
por: Bettedi, Lucia, et al.
Publicado: (2020)

Inactivation of the PI3K p110δ breaks regulatory T cell-mediated immune tolerance to cancer
por: Ali, Khaled, et al.
Publicado: (2014)

Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing
por: Bettedi, Lucia, et al.
Publicado: (2017)

Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity
por: Alliouachene, Samira, et al.
Publicado: (2015)

Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor
por: Berenjeno, Inma M., et al.
Publicado: (2012)

Antigen receptor signalling: a distinctive role for the p110δ isoform of PI3K
por: Okkenhaug, Klaus, et al.
Publicado: (2007)

Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling
por: Zhang, Biqin, et al.
Publicado: (2021)

Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability
por: Vanhaesebroeck, Bart, et al.
Publicado: (2019)

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
por: Soler, Adriana, et al.
Publicado: (2013)

The PI3K p110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1
por: Cain, Robert J., et al.
Publicado: (2010)

The p110δ of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation
por: Guo, Hailong, et al.
Publicado: (2008)

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons
por: Al-Qassab, Hind, et al.
Publicado: (2009)

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism
por: Bilanges, Benoit, et al.
Publicado: (2017)

Regulation of p110δ PI 3-Kinase Gene Expression
por: Kok, Klaartje, et al.
Publicado: (2009)

Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter
por: Whitehead, Maria A., et al.
Publicado: (2012)

Control of Axonal Growth and Regeneration of Sensory Neurons by the p110δ PI 3-Kinase
por: Eickholt, Britta J., et al.
Publicado: (2007)

Inhibition of p110δ PI3K prevents inflammatory response and restenosis after artery injury
por: Bilancio, Antonio, et al.
Publicado: (2017)

Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells
por: Guillermet-Guibert, Julie, et al.
Publicado: (2015)

Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach
por: Lauder, Sarah N., et al.
Publicado: (2021)

Inactivating the lipid kinase activity of PI3KC2β is sufficient to rescue myotubular myopathy in mice
por: Massana-Muñoz, Xènia, et al.
Publicado: (2023)

PI3Kα in cardioprotection: Cytoskeleton, late Na(+) current, and mechanism of arrhythmias
por: Zhabyeyev, Pavel, et al.
Publicado: (2019)

Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency
por: Grieco, Giuseppina, et al.
Publicado: (2018)

Pharmacological inactivation of the PI3K p110δ prevents breast tumour progression by targeting cancer cells and macrophages
por: Goulielmaki, Evangelia, et al.
Publicado: (2018)

The role of PI3Kα isoform in cardioprotection
por: Rossello, Xavier, et al.
Publicado: (2017)

Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α
por: Baer, Romain, et al.
Publicado: (2014)

Sparstolonin B exerts beneficial effects on prostate cancer by acting on the reactive oxygen species‐mediated PI3K/AKT pathway
por: Liu, Shaozhuang, et al.
Publicado: (2021)

Beneficial Effects Exerted by Paeonol in the Management of Atherosclerosis
por: Lu, Li, et al.
Publicado: (2018)

Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover
por: Posor, York, et al.
Publicado: (2022)

$\pi$p->$\pi$ $\pi$ N reactions near threshold-80-110
por: CERN. Geneva. Proton Synchrotron and Synchrocyclotron Committee
Publicado: (1980)

Treg-driven tumour control by PI3Kδ inhibition limits myeloid-derived suppressor cell expansion
por: Lauder, Sarah N., et al.
Publicado: (2022)

A Trifluoromethyl Analogue of Celecoxib Exerts Beneficial Effects in Neuroinflammation
por: Di Penta, Alessandra, et al.
Publicado: (2013)

SMER28 Attenuates PI3K/mTOR Signaling by Direct Inhibition of PI3K p110 Delta
por: Kirchenwitz, Marco, et al.
Publicado: (2022)

The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer
por: Zhang, Lei, et al.
Publicado: (2020)

Proposal for a 120 K exposure of $\pi$+ at 110 GeV/c in bare BEBC
por: Daugeras, B Y, et al.
Publicado: (1974)

The PI3K p110δ Regulates Expression of CD38 on Regulatory T Cells
por: Patton, Daniel T., et al.
Publicado: (2011)

Class IA PI3K regulatory subunits: p110-independent roles and structures
por: Fox, Millie, et al.
Publicado: (2020)

Ablation of PI3K-p110alpha Impairs Maternal Metabolic Adaptations to Pregnancy
por: Lopez-Tello, Jorge, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cuioj36vb11o482u7cd07j8t8s