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Hospital versus home treatment of respiratory exacerbations in cystic fibrosis
BACKGROUND: Treatment of respiratory exacerbations in Cystic Fibrosis (CF) is important in slowing disease progression. The treatment may be given either at home or at the hospital. The aim of our study was to compare both treatment settings. MATERIAL/METHODS: We retrospectively analyzed data of 139...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628126/ https://www.ncbi.nlm.nih.gov/pubmed/22129901 http://dx.doi.org/10.12659/MSM.882129 |
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author | Lavie, Moran Vilozni, Daphna Sokol, Gil Somech, Raz Szeinberg, Amir Efrati, Ori |
author_facet | Lavie, Moran Vilozni, Daphna Sokol, Gil Somech, Raz Szeinberg, Amir Efrati, Ori |
author_sort | Lavie, Moran |
collection | PubMed |
description | BACKGROUND: Treatment of respiratory exacerbations in Cystic Fibrosis (CF) is important in slowing disease progression. The treatment may be given either at home or at the hospital. The aim of our study was to compare both treatment settings. MATERIAL/METHODS: We retrospectively analyzed data of 139 treatments in 54 CF patients (age range12–47 y) treated for respiratory exacerbations at the hospital (n=84) and/or at home (n=55). Primary outcomes were improvement in pulmonary function tests (PFTs), weight gain and duration of treatment in relation to treatment setting. Secondary outcomes were these same parameters, but in relation to different clinical preconditions and CF-related complications. RESULTS: Mean improvement in FEV1 (% predicted) was similar between the hospital and home treatments (14.3±34.4% vs. 14.3±20.2%, respectively; NS), yet treatment duration was significantly shorter at the hospital (9.7±6.7 vs. 16.3±9.1 days, respectively; P<0.02), especially for patients colonized with Pseudomonas aeruginosa (11.1±5.5 vs. 18.0±11.0 days, respectively; p<0.01). At the hospital, a subgroup of patients with CF-related complications improved their FEV1 significantly more than those at home (13.1±19.4% vs. 1.9±14.9%, respectively; P<0.02), particularly patients with CF-related diabetes mellitus (CFRDM) (11.4±18.7% vs. 1.7±14.6%, respectively; P<0.05). Patients tended to gain more weight at the hospital compared to home treatment (1.36±4.6 kg and 0.49±3.6 kg respectively; P=0.06). CONCLUSIONS: Hospital treatment for acute respiratory exacerbations in CF may be superior to home treatment, as indicated by a shorter duration of hospitalization, better improvement in FEV1 in patients with CF-related complications, CFRDM in particular and a trend toward better weight gain. |
format | Online Article Text |
id | pubmed-3628126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-36281262013-04-24 Hospital versus home treatment of respiratory exacerbations in cystic fibrosis Lavie, Moran Vilozni, Daphna Sokol, Gil Somech, Raz Szeinberg, Amir Efrati, Ori Med Sci Monit Clinical Research BACKGROUND: Treatment of respiratory exacerbations in Cystic Fibrosis (CF) is important in slowing disease progression. The treatment may be given either at home or at the hospital. The aim of our study was to compare both treatment settings. MATERIAL/METHODS: We retrospectively analyzed data of 139 treatments in 54 CF patients (age range12–47 y) treated for respiratory exacerbations at the hospital (n=84) and/or at home (n=55). Primary outcomes were improvement in pulmonary function tests (PFTs), weight gain and duration of treatment in relation to treatment setting. Secondary outcomes were these same parameters, but in relation to different clinical preconditions and CF-related complications. RESULTS: Mean improvement in FEV1 (% predicted) was similar between the hospital and home treatments (14.3±34.4% vs. 14.3±20.2%, respectively; NS), yet treatment duration was significantly shorter at the hospital (9.7±6.7 vs. 16.3±9.1 days, respectively; P<0.02), especially for patients colonized with Pseudomonas aeruginosa (11.1±5.5 vs. 18.0±11.0 days, respectively; p<0.01). At the hospital, a subgroup of patients with CF-related complications improved their FEV1 significantly more than those at home (13.1±19.4% vs. 1.9±14.9%, respectively; P<0.02), particularly patients with CF-related diabetes mellitus (CFRDM) (11.4±18.7% vs. 1.7±14.6%, respectively; P<0.05). Patients tended to gain more weight at the hospital compared to home treatment (1.36±4.6 kg and 0.49±3.6 kg respectively; P=0.06). CONCLUSIONS: Hospital treatment for acute respiratory exacerbations in CF may be superior to home treatment, as indicated by a shorter duration of hospitalization, better improvement in FEV1 in patients with CF-related complications, CFRDM in particular and a trend toward better weight gain. International Scientific Literature, Inc. 2011-12-01 /pmc/articles/PMC3628126/ /pubmed/22129901 http://dx.doi.org/10.12659/MSM.882129 Text en © Med Sci Monit, 2011 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. |
spellingShingle | Clinical Research Lavie, Moran Vilozni, Daphna Sokol, Gil Somech, Raz Szeinberg, Amir Efrati, Ori Hospital versus home treatment of respiratory exacerbations in cystic fibrosis |
title | Hospital versus home treatment of respiratory exacerbations in cystic fibrosis |
title_full | Hospital versus home treatment of respiratory exacerbations in cystic fibrosis |
title_fullStr | Hospital versus home treatment of respiratory exacerbations in cystic fibrosis |
title_full_unstemmed | Hospital versus home treatment of respiratory exacerbations in cystic fibrosis |
title_short | Hospital versus home treatment of respiratory exacerbations in cystic fibrosis |
title_sort | hospital versus home treatment of respiratory exacerbations in cystic fibrosis |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628126/ https://www.ncbi.nlm.nih.gov/pubmed/22129901 http://dx.doi.org/10.12659/MSM.882129 |
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