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The Second Transmembrane Domain of P2X7 Contributes to Dilated Pore Formation

Activation of the purinergic receptor P2X7 leads to the cellular permeability of low molecular weight cations. To determine which domains of P2X7 are necessary for this permeability, we exchanged either the C-terminus or portions of the second transmembrane domain (TM2) with those in P2X1 or P2X4. R...

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Detalles Bibliográficos
Autores principales:	Sun, Chengqun, Heid, Michelle E., Keyel, Peter A., Salter, Russell D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629090/ https://www.ncbi.nlm.nih.gov/pubmed/23613968 http://dx.doi.org/10.1371/journal.pone.0061886

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