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Epigenetic effects of the natural flavonolignan silibinin on colon adenocarcinoma cells and their derived metastatic cells

Epigenetic modifications are important in tumorigenesis. The most frequent epigenetic phenomena in cancer are histone deacetylation and DNA hypermethylation, which lead to gene silencing, particularly of tumor suppressor genes. However, monotherapies with histone deacetylase (HDAC) or DNA methyltran...

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Detalles Bibliográficos
Autores principales:	KAUNTZ, HENRIETTE, BOUSSEROUEL, SOUAD, GOSSÉ, FRANCINE, RAUL, FRANCIS
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629096/ https://www.ncbi.nlm.nih.gov/pubmed/23599778 http://dx.doi.org/10.3892/ol.2013.1190

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