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Cyclopamine is a novel Hedgehog signaling inhibitor with significant anti-proliferative, anti-invasive and anti-estrogenic potency in human breast cancer cells

Stimulation of Hedgehog (Hh) signaling induces carcinogenesis or promotes cell survival in cancers of multiple organs. In epithelial cancer with aberrant Hedgehog activation, abrogation of Hedgehog signaling by cyclopamine, a naturally occurring Hedgehog-specific small-molecule inhibitor, causes pro...

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Detalles Bibliográficos
Autores principales:	CHE, JUN, ZHANG, FU-ZHENG, ZHAO, CHAO-QIAN, HU, XU-DONG, FAN, SAI-JUN
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629107/ https://www.ncbi.nlm.nih.gov/pubmed/23599805 http://dx.doi.org/10.3892/ol.2013.1195

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