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Genetic Polymorphisms of miR-146a and miR-27a, H. pylori Infection, and Risk of Gastric Lesions in a Chinese Population

BACKGROUND: MicroRNAs (miRNAs) have been implicated in various human diseases. Single nucleotide polymorphisms (SNPs) in inflammation-related miRNA may play an important role in Helicobacter pylori (H. pylori)-induced gastric lesions. To evaluate the associations between miRNA SNPs, H. pylori and ga...

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Autores principales: Song, Ming-yang, Su, Hui-juan, Zhang, Lian, Ma, Jun-ling, Li, Ji-you, Pan, Kai-feng, You, Wei-cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629121/
https://www.ncbi.nlm.nih.gov/pubmed/23613822
http://dx.doi.org/10.1371/journal.pone.0061250
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author Song, Ming-yang
Su, Hui-juan
Zhang, Lian
Ma, Jun-ling
Li, Ji-you
Pan, Kai-feng
You, Wei-cheng
author_facet Song, Ming-yang
Su, Hui-juan
Zhang, Lian
Ma, Jun-ling
Li, Ji-you
Pan, Kai-feng
You, Wei-cheng
author_sort Song, Ming-yang
collection PubMed
description BACKGROUND: MicroRNAs (miRNAs) have been implicated in various human diseases. Single nucleotide polymorphisms (SNPs) in inflammation-related miRNA may play an important role in Helicobacter pylori (H. pylori)-induced gastric lesions. To evaluate the associations between miRNA SNPs, H. pylori and gastric lesions, a population-based study was conducted in Linqu County, China. METHODOLOGY/PRINCIPAL FINDINGS: Based on serum miRNA array conducted in this population, two SNP loci (miR-146a rs2910164: G>C and miR-27a rs895819: T>C) were determined by polymerase chain reaction-restriction fragment length polymorphism in 2,380 participants with diverse gastric lesions. Using participants with superficial gastritis and mild chronic atrophic gastritis as the reference group, we found that rs2910164 CC carriers had a significantly increased risk of intestinal metaplasia [adjusted odds ratio (OR), 1.42; 95% confidence interval (CI), 1.03–1.97] and dysplasia (OR, 1.54; 95% CI, 1.05–2.25) compared to GG carriers, whereas no significant association was observed for rs895819. Stratified analysis by H. pylori infection indicated that rs2910164 C allele was associated with an increased risk of intestinal metaplasia and dysplasia only among individuals infected with H. pylori (CC vs. GG: OR, 1.53; 95% CI, 1.12–2.08, P for trend = 0.004). Participants who simultaneously carried variant alleles and H. pylori infection were more likely to develop intestinal metaplasia and dysplasia, although the interaction between genetic variants and H. pylori infection was not significant (P for interaction = 0.35 for rs2910164 and 0.92 for rs895819). CONCLUSIONS/SIGNIFICANCE: These findings suggest that miR-146a rs2910164 polymorphism may contribute to the evolution of H. pylori-associated gastric lesions in this high-risk population.
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spelling pubmed-36291212013-04-23 Genetic Polymorphisms of miR-146a and miR-27a, H. pylori Infection, and Risk of Gastric Lesions in a Chinese Population Song, Ming-yang Su, Hui-juan Zhang, Lian Ma, Jun-ling Li, Ji-you Pan, Kai-feng You, Wei-cheng PLoS One Research Article BACKGROUND: MicroRNAs (miRNAs) have been implicated in various human diseases. Single nucleotide polymorphisms (SNPs) in inflammation-related miRNA may play an important role in Helicobacter pylori (H. pylori)-induced gastric lesions. To evaluate the associations between miRNA SNPs, H. pylori and gastric lesions, a population-based study was conducted in Linqu County, China. METHODOLOGY/PRINCIPAL FINDINGS: Based on serum miRNA array conducted in this population, two SNP loci (miR-146a rs2910164: G>C and miR-27a rs895819: T>C) were determined by polymerase chain reaction-restriction fragment length polymorphism in 2,380 participants with diverse gastric lesions. Using participants with superficial gastritis and mild chronic atrophic gastritis as the reference group, we found that rs2910164 CC carriers had a significantly increased risk of intestinal metaplasia [adjusted odds ratio (OR), 1.42; 95% confidence interval (CI), 1.03–1.97] and dysplasia (OR, 1.54; 95% CI, 1.05–2.25) compared to GG carriers, whereas no significant association was observed for rs895819. Stratified analysis by H. pylori infection indicated that rs2910164 C allele was associated with an increased risk of intestinal metaplasia and dysplasia only among individuals infected with H. pylori (CC vs. GG: OR, 1.53; 95% CI, 1.12–2.08, P for trend = 0.004). Participants who simultaneously carried variant alleles and H. pylori infection were more likely to develop intestinal metaplasia and dysplasia, although the interaction between genetic variants and H. pylori infection was not significant (P for interaction = 0.35 for rs2910164 and 0.92 for rs895819). CONCLUSIONS/SIGNIFICANCE: These findings suggest that miR-146a rs2910164 polymorphism may contribute to the evolution of H. pylori-associated gastric lesions in this high-risk population. Public Library of Science 2013-04-17 /pmc/articles/PMC3629121/ /pubmed/23613822 http://dx.doi.org/10.1371/journal.pone.0061250 Text en © 2013 Song et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Song, Ming-yang
Su, Hui-juan
Zhang, Lian
Ma, Jun-ling
Li, Ji-you
Pan, Kai-feng
You, Wei-cheng
Genetic Polymorphisms of miR-146a and miR-27a, H. pylori Infection, and Risk of Gastric Lesions in a Chinese Population
title Genetic Polymorphisms of miR-146a and miR-27a, H. pylori Infection, and Risk of Gastric Lesions in a Chinese Population
title_full Genetic Polymorphisms of miR-146a and miR-27a, H. pylori Infection, and Risk of Gastric Lesions in a Chinese Population
title_fullStr Genetic Polymorphisms of miR-146a and miR-27a, H. pylori Infection, and Risk of Gastric Lesions in a Chinese Population
title_full_unstemmed Genetic Polymorphisms of miR-146a and miR-27a, H. pylori Infection, and Risk of Gastric Lesions in a Chinese Population
title_short Genetic Polymorphisms of miR-146a and miR-27a, H. pylori Infection, and Risk of Gastric Lesions in a Chinese Population
title_sort genetic polymorphisms of mir-146a and mir-27a, h. pylori infection, and risk of gastric lesions in a chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629121/
https://www.ncbi.nlm.nih.gov/pubmed/23613822
http://dx.doi.org/10.1371/journal.pone.0061250
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