Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein

BACE1 is responsible for β-secretase cleavage of the amyloid precursor protein (APP), which represents the first step in the production of amyloid β (Aβ) peptides. Previous reports, by us and others, have indicated that the levels of BACE1 protein and activity are increased in the brain cortex of pa...

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Detalles Bibliográficos
Autores principales: Tan, Jiang-Li, Li, Qiao-Xin, Ciccotosto, Giuseppe D., Crouch, Peter John, Culvenor, Janetta Gladys, White, Anthony Robert, Evin, Genevieve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629182/
https://www.ncbi.nlm.nih.gov/pubmed/23613819
http://dx.doi.org/10.1371/journal.pone.0061246

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