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miR-26a inhibits invasion and metastasis of nasopharyngeal cancer by targeting EZH2

Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic type of cancer that is widely prevalent in Southern China. Studies have shown that several microRNAs (miRNAs) are implicated in NPC metastasis. Our previous studies have demonstrated that miRNA miR-26a inhibits cell growth and tumori...

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Autores principales: YU, LI, LU, JUAN, ZHANG, BAO, LIU, XIONG, WANG, LU, LI, SI-YANG, PENG, XIAO-HONG, XU, XIA, TIAN, WEN-DONG, LI, XIANG-PING
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629195/
https://www.ncbi.nlm.nih.gov/pubmed/23599767
http://dx.doi.org/10.3892/ol.2013.1173
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author YU, LI
LU, JUAN
ZHANG, BAO
LIU, XIONG
WANG, LU
LI, SI-YANG
PENG, XIAO-HONG
XU, XIA
TIAN, WEN-DONG
LI, XIANG-PING
author_facet YU, LI
LU, JUAN
ZHANG, BAO
LIU, XIONG
WANG, LU
LI, SI-YANG
PENG, XIAO-HONG
XU, XIA
TIAN, WEN-DONG
LI, XIANG-PING
author_sort YU, LI
collection PubMed
description Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic type of cancer that is widely prevalent in Southern China. Studies have shown that several microRNAs (miRNAs) are implicated in NPC metastasis. Our previous studies have demonstrated that miRNA miR-26a inhibits cell growth and tumorigenesis of NPC through the repression of enhancer of zeste homolog 2 (EZH2). However, the role of miR-26a in NPC metastasis remains unknown. In this study, we showed that ectopic expression of miR-26a inhibited the migratory and invasive capacities of NPC cells in vitro. Additionally, we used a murine model to investigate the role of miR-26a in NPC metastasis and results showed that miR-26a overexpression suppresses the metastatic behavior of NPC cells in vivo. Furthermore, the data demonstrated that miR-26a decreased the expression levels of EZH2 in vitro and in vivo, suggesting that the antimetastatic effect of miR-26a in NPC was mediated by regulating EZH2. Therefore, these findings indicate that miR-26a functions as an antimetastatic miRNA in NPC and that its antimetastatic effects are mediated mainly by repressing EZH2 expression.
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spelling pubmed-36291952013-04-18 miR-26a inhibits invasion and metastasis of nasopharyngeal cancer by targeting EZH2 YU, LI LU, JUAN ZHANG, BAO LIU, XIONG WANG, LU LI, SI-YANG PENG, XIAO-HONG XU, XIA TIAN, WEN-DONG LI, XIANG-PING Oncol Lett Articles Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic type of cancer that is widely prevalent in Southern China. Studies have shown that several microRNAs (miRNAs) are implicated in NPC metastasis. Our previous studies have demonstrated that miRNA miR-26a inhibits cell growth and tumorigenesis of NPC through the repression of enhancer of zeste homolog 2 (EZH2). However, the role of miR-26a in NPC metastasis remains unknown. In this study, we showed that ectopic expression of miR-26a inhibited the migratory and invasive capacities of NPC cells in vitro. Additionally, we used a murine model to investigate the role of miR-26a in NPC metastasis and results showed that miR-26a overexpression suppresses the metastatic behavior of NPC cells in vivo. Furthermore, the data demonstrated that miR-26a decreased the expression levels of EZH2 in vitro and in vivo, suggesting that the antimetastatic effect of miR-26a in NPC was mediated by regulating EZH2. Therefore, these findings indicate that miR-26a functions as an antimetastatic miRNA in NPC and that its antimetastatic effects are mediated mainly by repressing EZH2 expression. D.A. Spandidos 2013-04 2013-02-04 /pmc/articles/PMC3629195/ /pubmed/23599767 http://dx.doi.org/10.3892/ol.2013.1173 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
YU, LI
LU, JUAN
ZHANG, BAO
LIU, XIONG
WANG, LU
LI, SI-YANG
PENG, XIAO-HONG
XU, XIA
TIAN, WEN-DONG
LI, XIANG-PING
miR-26a inhibits invasion and metastasis of nasopharyngeal cancer by targeting EZH2
title miR-26a inhibits invasion and metastasis of nasopharyngeal cancer by targeting EZH2
title_full miR-26a inhibits invasion and metastasis of nasopharyngeal cancer by targeting EZH2
title_fullStr miR-26a inhibits invasion and metastasis of nasopharyngeal cancer by targeting EZH2
title_full_unstemmed miR-26a inhibits invasion and metastasis of nasopharyngeal cancer by targeting EZH2
title_short miR-26a inhibits invasion and metastasis of nasopharyngeal cancer by targeting EZH2
title_sort mir-26a inhibits invasion and metastasis of nasopharyngeal cancer by targeting ezh2
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629195/
https://www.ncbi.nlm.nih.gov/pubmed/23599767
http://dx.doi.org/10.3892/ol.2013.1173
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