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In Vitro HIV-1 Evolution in Response to Triple Reverse Transcriptase Inhibitors & In Silico Phenotypic Analysis

BACKGROUND: Effectiveness of ART regimens strongly depends upon complex interactions between the selective pressure of drugs and the evolution of mutations that allow or restrict drug resistance. METHODS: Four clinical isolates from NRTI-exposed, NNRTI-naive subjects were passaged in increasing conc...

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Detalles Bibliográficos
Autores principales:	Rath, Barbara A., Yousef, Kaveh Pouran, Katzenstein, David K., Shafer, Robert W., Schütte, Christof, von Kleist, Max, Merigan, Thomas C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629221/ https://www.ncbi.nlm.nih.gov/pubmed/23613794 http://dx.doi.org/10.1371/journal.pone.0061102

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