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EZH2 Mutations Are Related to Low Blast Percentage in Bone Marrow and -7/del(7q) in De Novo Acute Myeloid Leukemia

The purpose of the present work was to determine the incidence and clinical implications of somatic EZH2 mutations in 714 patients with de novo acute myelogenous leukemia by sequencing the entire coding region. EZH2 mutations were identified in 13/714 (1.8%) of AML patients were found to be more com...

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Autores principales: Wang, Xiuli, Dai, Haiping, Wang, Qian, Wang, Qinrong, Xu, Yang, Wang, Ying, Sun, Aining, Ruan, Jia, Chen, Suning, Wu, Depei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629223/
https://www.ncbi.nlm.nih.gov/pubmed/23613835
http://dx.doi.org/10.1371/journal.pone.0061341
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author Wang, Xiuli
Dai, Haiping
Wang, Qian
Wang, Qinrong
Xu, Yang
Wang, Ying
Sun, Aining
Ruan, Jia
Chen, Suning
Wu, Depei
author_facet Wang, Xiuli
Dai, Haiping
Wang, Qian
Wang, Qinrong
Xu, Yang
Wang, Ying
Sun, Aining
Ruan, Jia
Chen, Suning
Wu, Depei
author_sort Wang, Xiuli
collection PubMed
description The purpose of the present work was to determine the incidence and clinical implications of somatic EZH2 mutations in 714 patients with de novo acute myelogenous leukemia by sequencing the entire coding region. EZH2 mutations were identified in 13/714 (1.8%) of AML patients were found to be more common in males (P = 0.033). The presence of EZH2 mutations was significantly associated with lower blast percentage (21–30%) in bone marrow (P<0.0001) and -7/del(7q) (P = 0.025). There were no differences in the incidence of mutation in 13 genes, ASXL1, CBL, c-KIT, DNMT3A, FLT3, IDH1, IDH2, MLL, NPM1, NRAS, RUNX1, TET2, and WT1, between patients with and without EZH2 mutations. No difference in complete remission, event-free survival, or overall survival was observed between patients with and without EZH2 mutation (P>0.05). Overall, these results showed EZH2 mutation in de novo acute myeloid leukemia as a recurrent genetic abnormality to be associated with lower blast percentage in BM and -7/del(7q).
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spelling pubmed-36292232013-04-23 EZH2 Mutations Are Related to Low Blast Percentage in Bone Marrow and -7/del(7q) in De Novo Acute Myeloid Leukemia Wang, Xiuli Dai, Haiping Wang, Qian Wang, Qinrong Xu, Yang Wang, Ying Sun, Aining Ruan, Jia Chen, Suning Wu, Depei PLoS One Research Article The purpose of the present work was to determine the incidence and clinical implications of somatic EZH2 mutations in 714 patients with de novo acute myelogenous leukemia by sequencing the entire coding region. EZH2 mutations were identified in 13/714 (1.8%) of AML patients were found to be more common in males (P = 0.033). The presence of EZH2 mutations was significantly associated with lower blast percentage (21–30%) in bone marrow (P<0.0001) and -7/del(7q) (P = 0.025). There were no differences in the incidence of mutation in 13 genes, ASXL1, CBL, c-KIT, DNMT3A, FLT3, IDH1, IDH2, MLL, NPM1, NRAS, RUNX1, TET2, and WT1, between patients with and without EZH2 mutations. No difference in complete remission, event-free survival, or overall survival was observed between patients with and without EZH2 mutation (P>0.05). Overall, these results showed EZH2 mutation in de novo acute myeloid leukemia as a recurrent genetic abnormality to be associated with lower blast percentage in BM and -7/del(7q). Public Library of Science 2013-04-17 /pmc/articles/PMC3629223/ /pubmed/23613835 http://dx.doi.org/10.1371/journal.pone.0061341 Text en © 2013 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wang, Xiuli
Dai, Haiping
Wang, Qian
Wang, Qinrong
Xu, Yang
Wang, Ying
Sun, Aining
Ruan, Jia
Chen, Suning
Wu, Depei
EZH2 Mutations Are Related to Low Blast Percentage in Bone Marrow and -7/del(7q) in De Novo Acute Myeloid Leukemia
title EZH2 Mutations Are Related to Low Blast Percentage in Bone Marrow and -7/del(7q) in De Novo Acute Myeloid Leukemia
title_full EZH2 Mutations Are Related to Low Blast Percentage in Bone Marrow and -7/del(7q) in De Novo Acute Myeloid Leukemia
title_fullStr EZH2 Mutations Are Related to Low Blast Percentage in Bone Marrow and -7/del(7q) in De Novo Acute Myeloid Leukemia
title_full_unstemmed EZH2 Mutations Are Related to Low Blast Percentage in Bone Marrow and -7/del(7q) in De Novo Acute Myeloid Leukemia
title_short EZH2 Mutations Are Related to Low Blast Percentage in Bone Marrow and -7/del(7q) in De Novo Acute Myeloid Leukemia
title_sort ezh2 mutations are related to low blast percentage in bone marrow and -7/del(7q) in de novo acute myeloid leukemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629223/
https://www.ncbi.nlm.nih.gov/pubmed/23613835
http://dx.doi.org/10.1371/journal.pone.0061341
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