Sirt1 activation by resveratrol is substrate sequence-selective

Sirtuins are protein deacetylases used as therapeutic targets. Pharmacological Sirt1 activation has been questioned since the in vitro activator resveratrol failed to stimulate deacetylation of several physiological substrates. We tested the influence of substrate sequence by analyzing resveratrol e...

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Detalles Bibliográficos
Autores principales: Lakshminarasimhan, Mahadevan, Rauh, David, Schutkowski, Mike, Steegborn, Clemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629287/
https://www.ncbi.nlm.nih.gov/pubmed/23524286

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