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Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange

Recently, minocycline, a tetracycline antibiotic, has been reported to improve symptoms of psychiatric disorders and to facilitate sober decision-making in healthy human subjects. Here we show that minocycline also reduces the risk of the ‘honey trap’ during an economic exchange. Males tend to coope...

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Autores principales: Watabe, Motoki, Kato, Takahiro A., Tsuboi, Sho, Ishikawa, Katsuhiko, Hashiya, Kazuhide, Monji, Akira, Utsumi, Hideo, Kanba, Shigenobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629414/
https://www.ncbi.nlm.nih.gov/pubmed/23595250
http://dx.doi.org/10.1038/srep01685
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author Watabe, Motoki
Kato, Takahiro A.
Tsuboi, Sho
Ishikawa, Katsuhiko
Hashiya, Kazuhide
Monji, Akira
Utsumi, Hideo
Kanba, Shigenobu
author_facet Watabe, Motoki
Kato, Takahiro A.
Tsuboi, Sho
Ishikawa, Katsuhiko
Hashiya, Kazuhide
Monji, Akira
Utsumi, Hideo
Kanba, Shigenobu
author_sort Watabe, Motoki
collection PubMed
description Recently, minocycline, a tetracycline antibiotic, has been reported to improve symptoms of psychiatric disorders and to facilitate sober decision-making in healthy human subjects. Here we show that minocycline also reduces the risk of the ‘honey trap’ during an economic exchange. Males tend to cooperate with physically attractive females without careful evaluation of their trustworthiness, resulting in betrayal by the female. In this experiment, healthy male participants made risky choices (whether or not to trust female partners, identified only by photograph, who had decided in advance to exploit the male participants). The results show that trusting behaviour in male participants significantly increased in relation to the perceived attractiveness of the female partner, but that attractiveness did not impact trusting behaviour in the minocycline group. Animal studies have shown that minocycline inhibits microglial activities. Therefore, this minocycline effect may shed new light on the unknown roles microglia play in human mental activities.
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spelling pubmed-36294142013-04-18 Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange Watabe, Motoki Kato, Takahiro A. Tsuboi, Sho Ishikawa, Katsuhiko Hashiya, Kazuhide Monji, Akira Utsumi, Hideo Kanba, Shigenobu Sci Rep Article Recently, minocycline, a tetracycline antibiotic, has been reported to improve symptoms of psychiatric disorders and to facilitate sober decision-making in healthy human subjects. Here we show that minocycline also reduces the risk of the ‘honey trap’ during an economic exchange. Males tend to cooperate with physically attractive females without careful evaluation of their trustworthiness, resulting in betrayal by the female. In this experiment, healthy male participants made risky choices (whether or not to trust female partners, identified only by photograph, who had decided in advance to exploit the male participants). The results show that trusting behaviour in male participants significantly increased in relation to the perceived attractiveness of the female partner, but that attractiveness did not impact trusting behaviour in the minocycline group. Animal studies have shown that minocycline inhibits microglial activities. Therefore, this minocycline effect may shed new light on the unknown roles microglia play in human mental activities. Nature Publishing Group 2013-04-18 /pmc/articles/PMC3629414/ /pubmed/23595250 http://dx.doi.org/10.1038/srep01685 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Watabe, Motoki
Kato, Takahiro A.
Tsuboi, Sho
Ishikawa, Katsuhiko
Hashiya, Kazuhide
Monji, Akira
Utsumi, Hideo
Kanba, Shigenobu
Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange
title Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange
title_full Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange
title_fullStr Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange
title_full_unstemmed Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange
title_short Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange
title_sort minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629414/
https://www.ncbi.nlm.nih.gov/pubmed/23595250
http://dx.doi.org/10.1038/srep01685
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