KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West: Results from a large international multicentre study

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BACKGROUND: Inhibitors of the epidermal growth factor (EGFR) signaling pathway have a major role in the treatment of KRAS wild-type colorectal cancer patients. The EGFR pathway has been shown to be activated in gastric cancer (GC). However, published data on KRAS and BRAF mutation status is limited...

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Detalles Bibliográficos
Autores principales: van Grieken, N C T, Aoyma, T, Chambers, P A, Bottomley, D, Ward, L C, Inam, I, Buffart, T E, Das, K, Lim, T, Pang, B, Zhang, S L, Tan, I B, Carvalho, B, Heideman, D A M, Miyagi, Y, Kameda, Y, Arai, T, Meijer, G A, Tsuburaya, A, Tan, P, Yoshikawa, T, Grabsch, H I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629423/
https://www.ncbi.nlm.nih.gov/pubmed/23511561
http://dx.doi.org/10.1038/bjc.2013.109
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