Direct Competition between hnRNP C and U2AF65 Protects the Transcriptome from the Exonization of Alu Elements

There are ∼650,000 Alu elements in transcribed regions of the human genome. These elements contain cryptic splice sites, so they are in constant danger of aberrant incorporation into mature transcripts. Despite posing a major threat to transcriptome integrity, little is known about the molecular mec...

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Detalles Bibliográficos
Autores principales: Zarnack, Kathi, König, Julian, Tajnik, Mojca, Martincorena, Iñigo, Eustermann, Sebastian, Stévant, Isabelle, Reyes, Alejandro, Anders, Simon, Luscombe, Nicholas M., Ule, Jernej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629564/
https://www.ncbi.nlm.nih.gov/pubmed/23374342
http://dx.doi.org/10.1016/j.cell.2012.12.023

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