Cargando…
Short Telomeres in ESCs Lead to Unstable Differentiation
Functional telomeres are critical for stem cell proliferation; however, whether they are equally important for the stability of stem cell differentiation is not known. We found that mouse embryonic stem cells (ESCs) with critically short telomeres (Tert(−/−) ESCs) initiated normal differentiation af...
Autores principales: | Pucci, Fabio, Gardano, Laura, Harrington, Lea |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629568/ https://www.ncbi.nlm.nih.gov/pubmed/23561444 http://dx.doi.org/10.1016/j.stem.2013.01.018 |
Ejemplares similares
-
Telomeres, A Busy Platform for Cell Signaling
por: Gardano, Laura, et al.
Publicado: (2013) -
In medio stat virtus: unanticipated consequences of telomere dysequilibrium
por: Harrington, Lea, et al.
Publicado: (2018) -
Lung Fibroblasts from Idiopathic Pulmonary Fibrosis Patients Harbor Short and Unstable Telomeres Leading to Chromosomal Instability
por: M’Kacher, Radhia, et al.
Publicado: (2022) -
Human ESCs predisposition to karyotypic instability: Is a matter of culture adaptation or differential vulnerability among hESC lines due to inherent properties?
por: Catalina, Puri, et al.
Publicado: (2008) -
Esc2 promotes telomere stability in response to DNA replication stress
por: Jørgensen, Signe W, et al.
Publicado: (2019)