N-(2,6-Dimeth­oxy­pyridin-3-yl)-9-methyl-9H-carbazole-3-sulfonamide

In the title compound, C(20)H(19)N(3)O(4)S, a novel tubulin ligand active against human cancer, the dihedral angle between the pyridine ring and the carbazole ring system is 42.87 (10)°. In the crystal, the mol­ecules are held together by N—H⋯O and C—H⋯O hydrogen bonds into layers, which are assembl...

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Detalles Bibliográficos
Autores principales: Shan, Guangzhi, Li, Zhuorong, Hu, Laixing, Jiang, Jiandong, Liu, Zongying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2013
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629629/
https://www.ncbi.nlm.nih.gov/pubmed/23634116
http://dx.doi.org/10.1107/S1600536813007460
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author Shan, Guangzhi
Li, Zhuorong
Hu, Laixing
Jiang, Jiandong
Liu, Zongying
author_facet Shan, Guangzhi
Li, Zhuorong
Hu, Laixing
Jiang, Jiandong
Liu, Zongying
author_sort Shan, Guangzhi
collection PubMed
description In the title compound, C(20)H(19)N(3)O(4)S, a novel tubulin ligand active against human cancer, the dihedral angle between the pyridine ring and the carbazole ring system is 42.87 (10)°. In the crystal, the mol­ecules are held together by N—H⋯O and C—H⋯O hydrogen bonds into layers, which are assembled into a three-dimensional network via π–π stacking inter­actions between inversion-related pyridine rings, with centroid–centroid distances of 3.5101 (12) Å.
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spelling pubmed-36296292013-04-30 N-(2,6-Dimeth­oxy­pyridin-3-yl)-9-methyl-9H-carbazole-3-sulfonamide Shan, Guangzhi Li, Zhuorong Hu, Laixing Jiang, Jiandong Liu, Zongying Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(20)H(19)N(3)O(4)S, a novel tubulin ligand active against human cancer, the dihedral angle between the pyridine ring and the carbazole ring system is 42.87 (10)°. In the crystal, the mol­ecules are held together by N—H⋯O and C—H⋯O hydrogen bonds into layers, which are assembled into a three-dimensional network via π–π stacking inter­actions between inversion-related pyridine rings, with centroid–centroid distances of 3.5101 (12) Å. International Union of Crystallography 2013-03-23 /pmc/articles/PMC3629629/ /pubmed/23634116 http://dx.doi.org/10.1107/S1600536813007460 Text en © Shan et al. 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Shan, Guangzhi
Li, Zhuorong
Hu, Laixing
Jiang, Jiandong
Liu, Zongying
N-(2,6-Dimeth­oxy­pyridin-3-yl)-9-methyl-9H-carbazole-3-sulfonamide
title N-(2,6-Dimeth­oxy­pyridin-3-yl)-9-methyl-9H-carbazole-3-sulfonamide
title_full N-(2,6-Dimeth­oxy­pyridin-3-yl)-9-methyl-9H-carbazole-3-sulfonamide
title_fullStr N-(2,6-Dimeth­oxy­pyridin-3-yl)-9-methyl-9H-carbazole-3-sulfonamide
title_full_unstemmed N-(2,6-Dimeth­oxy­pyridin-3-yl)-9-methyl-9H-carbazole-3-sulfonamide
title_short N-(2,6-Dimeth­oxy­pyridin-3-yl)-9-methyl-9H-carbazole-3-sulfonamide
title_sort n-(2,6-dimeth­oxy­pyridin-3-yl)-9-methyl-9h-carbazole-3-sulfonamide
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629629/
https://www.ncbi.nlm.nih.gov/pubmed/23634116
http://dx.doi.org/10.1107/S1600536813007460
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