A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC(50)≤0.5 µM), and was posited to exploit the physiological difference between static viral membranes and biogenic cellular membranes. We now report on the molecular...

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Detalles Bibliográficos
Autores principales: Vigant, Frederic, Lee, Jihye, Hollmann, Axel, Tanner, Lukas B., Akyol Ataman, Zeynep, Yun, Tatyana, Shui, Guanghou, Aguilar, Hector C., Zhang, Dong, Meriwether, David, Roman-Sosa, Gleyder, Robinson, Lindsey R., Juelich, Terry L., Buczkowski, Hubert, Chou, Sunwen, Castanho, Miguel A. R. B., Wolf, Mike C., Smith, Jennifer K., Banyard, Ashley, Kielian, Margaret, Reddy, Srinivasa, Wenk, Markus R., Selke, Matthias, Santos, Nuno C., Freiberg, Alexander N., Jung, Michael E., Lee, Benhur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630091/
https://www.ncbi.nlm.nih.gov/pubmed/23637597
http://dx.doi.org/10.1371/journal.ppat.1003297

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