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Cytotoxic Chromosomal Targeting by CRISPR/Cas Systems Can Reshape Bacterial Genomes and Expel or Remodel Pathogenicity Islands

In prokaryotes, clustered regularly interspaced short palindromic repeats (CRISPRs) and their associated (Cas) proteins constitute a defence system against bacteriophages and plasmids. CRISPR/Cas systems acquire short spacer sequences from foreign genetic elements and incorporate these into their CR...

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Detalles Bibliográficos
Autores principales:	Vercoe, Reuben B., Chang, James T., Dy, Ron L., Taylor, Corinda, Gristwood, Tamzin, Clulow, James S., Richter, Corinna, Przybilski, Rita, Pitman, Andrew R., Fineran, Peter C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630108/ https://www.ncbi.nlm.nih.gov/pubmed/23637624 http://dx.doi.org/10.1371/journal.pgen.1003454

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