Cleavage Entropy as Quantitative Measure of Protease Specificity

A purely information theory-guided approach to quantitatively characterize protease specificity is established. We calculate an entropy value for each protease subpocket based on sequences of cleaved substrates extracted from the MEROPS database. We compare our results with known subpocket specifici...

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Detalles Bibliográficos
Autores principales: Fuchs, Julian E., von Grafenstein, Susanne, Huber, Roland G., Margreiter, Michael A., Spitzer, Gudrun M., Wallnoefer, Hannes G., Liedl, Klaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630115/
https://www.ncbi.nlm.nih.gov/pubmed/23637583
http://dx.doi.org/10.1371/journal.pcbi.1003007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630115/
https://www.ncbi.nlm.nih.gov/pubmed/23637583
http://dx.doi.org/10.1371/journal.pcbi.1003007

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