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A Single Amino Acid Substitution in the Group 1 Trypanosoma brucei gambiense Haptoglobin-Hemoglobin Receptor Abolishes TLF-1 Binding

Critical to human innate immunity against African trypanosomes is a minor subclass of human high-density lipoproteins, termed Trypanosome Lytic Factor-1 (TLF-1). This primate-specific molecule binds to a haptoglobin-hemoglobin receptor (HpHbR) on the surface of susceptible trypanosomes, initiating a...

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Detalles Bibliográficos
Autores principales:	DeJesus, E., Kieft, R., Albright, B., Stephens, N. A., Hajduk, S. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630162/ https://www.ncbi.nlm.nih.gov/pubmed/23637606 http://dx.doi.org/10.1371/journal.ppat.1003317

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